Known targets — ChEMBL curated mechanism
ABL1BMXBRAFBTKCHRNA4CHRNB2CSNK1EEGFRERBB2F10FLT1FLT3FLT4IGF1RINSRITKJAK3KDRKITOPRM1PARP1PARP2PDGFRBPIK3CDRAF1RETSLC18A2TECTXKdacAdacBdacCftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 5/20 | 0.46 |
| ▸ | CA2 | P00918 | 5/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | FKBP1A | P62942 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | CTSC | P53634 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ELANE | P08246 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3930177 | 1.00 | TSHR (0.47) | TSHRCA1CA2LMNAFKBP1A | |
| SCHEMBL5549483 | 0.88 | ALDH1A1 (0.44) | FKBP1AMAPTCTSCHPGDALDH1A1 | |
| SCHEMBL5461273 | 0.86 | TSHR (0.56) | TSHRFKBP1AALDH1A1 | |
| SCHEMBL6871388 | 0.86 | TSHR (0.56) | TSHRFKBP1AALDH1A1 | |
| SCHEMBL13314011 | 0.86 | TSHR (0.56) | TSHRFKBP1AALDH1A1 | |
| SCHEMBL14605828 | 0.86 | TSHR (0.56) | TSHRFKBP1AALDH1A1 | |
| SCHEMBL9169159 | 0.86 | TSHR (0.56) | TSHRFKBP1AALDH1A1 | |
| SCHEMBL2178522 | 0.86 | TSHR (0.56) | TSHRFKBP1AALDH1A1 | |
| SCHEMBL14117906 | 0.86 | TSHR (0.56) | TSHRFKBP1AALDH1A1 | |
| SCHEMBL9733234 | 0.86 | TSHR (0.56) | TSHRFKBP1AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113980096-A | Process for synthesizing ton-grade perindopril tert-butylamine | 绍兴市上虞区武汉理工大学高等研究院 | 2022-01-28 | — | — | CN | claimed |
| CN-113980096-A | Process for synthesizing ton-grade perindopril tert-butylamine | 绍兴市上虞区武汉理工大学高等研究院 | 2022-01-28 | — | — | CN | disclosed |
| CN-113980096-A | Process for synthesizing ton-grade perindopril tert-butylamine | 绍兴市上虞区武汉理工大学高等研究院 | 2022-01-28 | — | — | CN | disclosed |
| EP-2906536-B1 | AN IMPROVED PROCESS FOR PREPARATION OF PERINDOPRIL INTERMEDIATE | PIRAMAL ENTPR LTD (IN) | 2018-03-14 | — | — | EP | disclosed |
| US-20150252001-A1 | PROCESS FOR PREPARATION OF PERINDOPRIL INTERMEDIATE | Piramal Enterprises Limited (IN) | 2015-09-10 | — | — | US | disclosed |
| US-20150252001-A1 | PROCESS FOR PREPARATION OF PERINDOPRIL INTERMEDIATE | Piramal Enterprises Limited (IN) | 2015-09-10 | — | — | US | disclosed |
| EP-2906536-A1 | AN IMPROVED PROCESS FOR PREPARATION OF PERINDOPRIL INTERMEDIATE | Piramal Enterprises Limited (IN) | 2015-08-19 | — | — | EP | disclosed |
| WO-2014057404-A1 | AN IMPROVED PROCESS FOR PREPARATION OF PERINDOPRIL INTERMEDIATE | Piramal Enterprises Limited (IN) | 2014-04-17 | — | — | WO | disclosed |
| EP-2044010-B1 | NEW PHARMACEUTICAL INTERMEDIATES IN THE SYNTHESIS OF ACE-INIHIBITORS AND THE USE THEREOF | EGIS GYOGYSZERGYAR NYILVANOSAN MUEKOEDO RESZVENYTARSASAG (HU) | 2014-01-08 | — | — | EP | disclosed |
| US-7960558-B2 | Pharmaceutical intermediate for synthesizing ACE inhibitors and the use thereof | EGIS GYOGYSZERGYAR NYILVANOSAN MUKODO RESZVENYTARSASAG (HU) | 2011-06-14 | — | — | US | disclosed |
| US-7456296-B2 | Method for preparation of crystalline perindopril erbumine | LUPIN LTD (IN) | 2008-11-25 | — | — | US | disclosed |
| EP-1943267-A1 | A PROCESS FOR THE PREPARATION OF PERINDOPRIL ERBUMINE | LEK Pharmaceuticals D.D. (SI) | 2008-07-16 | — | — | EP | disclosed |
| US-7288661-B2 | Process for the synthesis of (2S,3aS,7aS)-1-[(S)-alanyl]-octahydro-1H-indole-2-carboxylic acid compounds and application in the synthesis of perindopril | LES LABORATOIRES SERVIER (FR) | 2007-10-30 | — | — | US | disclosed |
| US-7279583-B2 | Process for the synthesis of perindopril and pharmaceutically acceptable salts thereof | LES LABORATOIRES SERVIER (FR) | 2007-10-09 | — | — | US | disclosed |
| US-20070149604-A1 | Reacting perindopril in a solvent selected from N,N-dimethylformamide, dimethoxymethane, 2,2-dimethoxypropane and 1,2-dimethoxyethane with tert-butylamine, crystallization; stereospecific | LUPIN LTD. (IN) | 2007-06-28 | — | — | US | disclosed |
| US-20070123581-A1 | Process for the synthesis of (2s, 3as, 7as)-1-[(s)-alanyl]-octahydro-1h-indole-2-carboxylic acid compounds and application in the synthesis of perindopril | LES LABORATOIRES SERVIER (FR) | 2007-05-31 | — | — | US | disclosed |
| US-20070093663-A1 | Process for the synthesis of perindopril and pharmaceutically acceptable salts thereof. | LES LABORATOIRES SERVIER (FR) | 2007-04-26 | — | — | US | disclosed |
| WO-2007020012-A1 | A PROCESS FOR THE PREPARATION OF PERINDOPRIL ERBUMINE | LEK PHARMACEUTICALS D.D. (SI) | 2007-02-22 | — | — | WO | disclosed |
| US-6835843-B2 | Amidation, deprotected by catalytic hydrogenation, salt formation with tributylamine | LES LABORATOIRES SERVIER (FR) | 2004-12-28 | — | — | US | disclosed |
| US-20030069431-A1 | Method for synthesis of perindopril and its pharmaceutically acceptable salts | LES LABORATOIRES SERVIER (FR) | 2003-04-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150252001-A1 | PROCESS FOR PREPARATION OF PERINDOPRIL INTERMEDIATE | PAH, HTR3B, TPMT | TSHR 2719/4885CA1 3276/4885CA2 1990/4885 |
| US-20070093663-A1 | Process for the synthesis of perindopril and pharmaceutically acceptable salts thereof. | QDPR, REN, ACE | TSHR 4035/4885CA1 4683/4885CA2 3189/4885 |
| US-20030069431-A1 | Method for synthesis of perindopril and its pharmaceutically acceptable salts | ACE, REN, DPYD | TSHR 3776/4885CA1 4096/4885CA2 1908/4885 |
| US-20070123581-A1 | Process for the synthesis of (2s, 3as, 7as)-1-[(s)-alanyl]-octahydro-1h-indole-2-carboxylic acid compounds and application in the synthesis of perindopril | CYP2S1, TPH1, AGTR1 | TSHR 2979/4885CA1 2155/4885CA2 714/4885 |
| US-20070149604-A1 | Reacting perindopril in a solvent selected from N,N-dimethylformamide, dimethoxymethane, 2,2-dimethoxypropane and 1,2-dimethoxyethane with tert-butylamine, crystallization; stereospecific | REN, AGTR2, AGTR1 | TSHR 2109/4885CA1 3896/4885CA2 2137/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.