Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | F2 | P00734 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | KCNA5 | P22460 | 5/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3928404 | 0.82 | ALDH1A1 (0.58) | ALDH1A1LMNASMN1; SMN2F2MEN1 | |
| SCHEMBL3932048 | 0.81 | ALDH1A1 (0.52) | ALDH1A1LMNASMN1; SMN2F2MEN1 | |
| SCHEMBL14863729 | 0.78 | HPGD (0.46) | ALDH1A1LMNAMEN1KMT2AKCNA5 | |
| SCHEMBL18669194 | 0.76 | GAA (0.59) | ALDH1A1LMNAMEN1KMT2AMAPT | |
| SCHEMBL4164264 | 0.75 | KCNA5 (0.56) | ALDH1A1LMNASMN1; SMN2F2MEN1 | |
| SCHEMBL13684839 | 0.71 | FFAR1 (0.45) | ALDH1A1LMNAMEN1KMT2AMAPT | |
| SCHEMBL3932445 | 0.69 | ALDH1A1 (0.56) | ALDH1A1LMNASMN1; SMN2F2MEN1 | |
| SCHEMBL3936780 | 0.68 | THRB (0.55) | ALDH1A1LMNASMN1; SMN2F2MEN1 | |
| SCHEMBL8342657 | 0.68 | KDM4E (0.47) | ALDH1A1SMN1; SMN2MEN1KMT2AMAPT | |
| SCHEMBL2643388 | 0.67 | MAPT (0.55) | ALDH1A1LMNASMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044019-A1 | 3-OXOISOINDOLINE-1-CARBOXAMIDE DERIVATIVES AS ANALGESIC AGENTS | Astra Zeneca AB (SE) | 2009-04-08 | — | — | EP | disclosed |
| WO-2008008020-A1 | 3-OXOISOINDOLINE-1-CARBOXAMIDE DERIVATIVES AS ANALGESIC AGENTS | ASTRAZENECA AB (SE) | 2008-01-17 | — | — | WO | disclosed |