Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | KCNA5 | P22460 | 6/20 | 0.56 |
| ▸ | F2 | P00734 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3932445 | 0.89 | ALDH1A1 (0.56) | ALDH1A1LMNASMN1; SMN2KCNA5F2 | |
| SCHEMBL3932048 | 0.88 | ALDH1A1 (0.52) | ALDH1A1LMNASMN1; SMN2KCNA5F2 | |
| SCHEMBL4164264 | 0.83 | KCNA5 (0.56) | ALDH1A1LMNASMN1; SMN2KCNA5F2 | |
| SCHEMBL3932009 | 0.82 | ALDH1A1 (0.46) | ALDH1A1LMNASMN1; SMN2KCNA5F2 | |
| SCHEMBL3936780 | 0.76 | THRB (0.55) | ALDH1A1LMNASMN1; SMN2KCNA5F2 | |
| SCHEMBL18669194 | 0.75 | GAA (0.59) | ALDH1A1LMNAMEN1KMT2ARECQL | |
| SCHEMBL2644659 | 0.75 | FFAR1 (0.55) | ALDH1A1LMNASMN1; SMN2F2MEN1 | |
| SCHEMBL3750006 | 0.74 | ALDH1A1 (0.66) | ALDH1A1LMNASMN1; SMN2KCNA5F2 | |
| SCHEMBL3745607 | 0.74 | KCNA5 (0.67) | KCNA5KCNH2 | |
| SCHEMBL3754130 | 0.74 | KCNA5 (0.73) | ALDH1A1LMNASMN1; SMN2KCNA5F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090291983-A1 | 3-Oxoisoindoline-1-Carboxamide Derivatives as Analgesic Agents | ASTRAZENECA AB (SE) | 2009-11-26 | — | — | US | disclosed |
| EP-2044019-A1 | 3-OXOISOINDOLINE-1-CARBOXAMIDE DERIVATIVES AS ANALGESIC AGENTS | Astra Zeneca AB (SE) | 2009-04-08 | — | — | EP | disclosed |
| WO-2008008020-A1 | 3-OXOISOINDOLINE-1-CARBOXAMIDE DERIVATIVES AS ANALGESIC AGENTS | ASTRAZENECA AB (SE) | 2008-01-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090291983-A1 | 3-Oxoisoindoline-1-Carboxamide Derivatives as Analgesic Agents | OPRD1, OPRK1, OPRM1 | ALDH1A1 429/4885LMNA 3171/4885SMN1; SMN2 585/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.