SCHEMBL3932286

SCHEMBL3932286

O=C(O)Cc1cccc(C2CN(S(=O)(=O)c3ccc(F)cc3)CCC2C2CCCCC2)c1

nearest known ligand 0.45

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.45
PTGDR2 Q9Y5Y4 5/20 0.44
KDM4E B2RXH2 2/20 0.44
GAA P10253 2/20 0.44
PKM P14618 2/20 0.43
TSHR P16473 1/20 0.43
KMT2A Q03164 5/20 0.43
CYP3A4 P08684 1/20 0.43
CYP2C19 P33261 1/20 0.43
USP5 P45974 2/20 0.42
EPHX2 P34913 1/20 0.42
L3MBTL1 Q9Y468 1/20 0.42
LMNA P02545 1/20 0.41
HTT P42858 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3931870 0.87 PTGDR2 (0.49) MAPTPTGDR2PKMTSHRKMT2A
SCHEMBL3934209 0.86 USP5 (0.47) MAPTPTGDR2KDM4EPKMTSHR
SCHEMBL3941103 0.84 PTGDR2 (0.47) MAPTPTGDR2PKMTSHRKMT2A
SCHEMBL3938376 0.83 PTGDR2 (0.54) MAPTPTGDR2PKMTSHRKMT2A
Fluorobenzene SCHEMBL28776689 0.83 PKM (0.39) PTGDR2PKMTSHRUSP5
SCHEMBL3941517 0.82 MAPT (0.55) MAPTPTGDR2KDM4EGAATSHR
SCHEMBL3938045 0.82 MAPT (0.55) MAPTPTGDR2KDM4EGAATSHR
SCHEMBL3929084 0.82 MAPT (0.55) MAPTPTGDR2KDM4EGAATSHR
SCHEMBL3942010 0.81 USP5 (0.61) PTGDR2PKMTSHRKMT2AUSP5
SCHEMBL14366366 0.77 PKM (0.49) MAPTKDM4EGAAPKMTSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2044017-A2 SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS ICOS CORPORATION (US) 2009-04-08 EP claimed
WO-2007146838-A2 SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS ICOS CORPORATION (US) 2007-12-21 WO claimed
EP-2044017-A2 SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS ICOS CORPORATION (US) 2009-04-08 EP disclosed
WO-2007146838-A2 SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS ICOS CORPORATION (US) 2007-12-21 WO disclosed
WO-2007146838-A2 SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS ICOS CORPORATION (US) 2007-12-21 WO disclosed