SCHEMBL393244

SCHEMBL393244

C=C(C)C(=O)OC[Si](O)(O[Si](C)(C)C)O[Si](C)(C)C

nearest known ligand 0.42

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.42
ALDH1A1 P00352 2/20 0.42
THRB P10828 1/20 0.40
POLB P06746 1/20 0.30
APEX1 P27695 1/20 0.30
HTT P42858 1/20 0.30
TDP1 Q9NUW8 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18960286 0.93 TSHR (0.38) TSHRALDH1A1THRB
SCHEMBL9819968 0.92 TSHR (0.37) TSHRALDH1A1THRB
SCHEMBL10793406 0.89 TSHR (0.35) TSHRALDH1A1THRB
SCHEMBL396535 0.85 TSHR (0.42) TSHRALDH1A1THRBPOLBAPEX1
SCHEMBL332603 0.82 TSHR (0.44) TSHRALDH1A1THRBPOLBAPEX1
SCHEMBL9411488 0.82 TSHR (0.44) TSHRALDH1A1THRBPOLBAPEX1
SCHEMBL1046024 0.82 TSHR (0.44) TSHRALDH1A1THRBPOLBAPEX1
SCHEMBL396761 0.82 TSHR (0.48) TSHRALDH1A1THRBPOLBAPEX1
SCHEMBL9715006 0.81 THRB (0.46) TSHRALDH1A1THRBPOLBAPEX1
SCHEMBL4583359 0.81 TSHR (0.50) TSHRALDH1A1THRBPOLBAPEX1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0242080-B1 COPOLYMER COMPOSITIONS PARAGON OPTICAL INC (US) 1992-12-16 EP claimed
US-4661573-A INTRAOCULAR AND CONTACT LENSES; COPOLYMER OF PERFLUROALKYL ACRYLATE, ACRYLOXYALKYLPOLYSILOXANE, ACRYLOXYALKYLSILANOL, POLYACRYLOXYALKYLPOLYSILOXANE PARAGON OPTICAL INC. (US) 1987-04-28 US claimed
US-8110697-B2 Method for the production of polymerizable silicones WACKER CHEMIE AG (DE) 2012-02-07 US disclosed
US-8101789-B2 Method for the production of polymerizable silicones WACKER CHEMIE AG (DE) 2012-01-24 US disclosed
EP-2125833-B1 METHOD FOR THE PRODUCTION OF POLYMERISABLE SILICONES WACKER CHEMIE AG (DE) 2010-08-25 EP disclosed
EP-2125834-B1 METHOD FOR THE PRODUCTION OF POLYMERISABLE SILICONES WACKER CHEMIE AG (DE) 2010-08-25 EP disclosed
US-20100041909-A1 METHOD FOR THE PRODUCTION OF POLYMERIZABLE SILICONES WACKER CHEMIE AG (DE) 2010-02-18 US disclosed
US-20100029972-A1 METHOD FOR THE PRODUCTION OF POLYMERIZABLE SILICONES WACKER CHEMIE AG (DE) 2010-02-04 US disclosed
EP-0242080-B1 COPOLYMER COMPOSITIONS PARAGON OPTICAL INC (US) 1992-12-16 EP disclosed
EP-0215817-B1 CONTINUOUS-WEAR LENSES Bausch & Lomb Incorporated (US) 1991-03-13 EP disclosed
EP-0192683-B1 LENS COMPOSITION, ARTICLE AND METHOD OF MANUFACTURE PARAGON OPTICAL INC (US) 1989-12-20 EP disclosed
EP-0242080-A2 Copolymer compositions PARAGON OPTICAL INC (US) 1987-10-21 EP disclosed
US-4661573-A INTRAOCULAR AND CONTACT LENSES; COPOLYMER OF PERFLUROALKYL ACRYLATE, ACRYLOXYALKYLPOLYSILOXANE, ACRYLOXYALKYLSILANOL, POLYACRYLOXYALKYLPOLYSILOXANE PARAGON OPTICAL INC. (US) 1987-04-28 US disclosed
EP-0215817-A1 CONTINUOUS-WEAR LENSES. BAUSCH & LOMB (US) 1987-04-01 EP disclosed
EP-0192683-A4 LENS COMPOSITION, ARTICLE AND METHOD OF MANUFACTURE. PARAGON OPTICAL INC (US) 1987-02-19 EP disclosed
EP-0192683-A1 LENS COMPOSITION, ARTICLE AND METHOD OF MANUFACTURE. PARAGON OPTICAL INC (US) 1986-09-03 EP disclosed
WO-1986004341-A1 CONTINUOUS-WEAR LENSES BAUSCH AND LOMB INCORPORATED (US) 1986-07-31 WO disclosed
EP-0184924-A2 Lens composition, articles and method of manufacture PARAGON OPTICAL INC (US) 1986-06-18 EP disclosed
US-4582884-A Lens composition, article and method of manufacture PARAGON OPTICAL, INC. (US) 1986-04-15 US disclosed
WO-1986001518-A1 LENS COMPOSITION, ARTICLE AND METHOD OF MANUFACTURE PARAGON OPTICAL, INC. (US) 1986-03-13 WO disclosed