Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.58 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.58 |
| ▸ | SYK | P43405 | 1/20 | 0.53 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.51 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.51 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.51 |
| ▸ | KMO | O15229 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.48 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.48 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.48 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.47 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.47 |
| ▸ | KLK1 | P06870 | 1/20 | 0.47 |
| ▸ | CTSV | O60911 | 1/20 | 0.47 |
| ▸ | CTSL | P07711 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9709514 | 0.86 | EPHX2 (0.52) | ALDH1A1KDM4ENPC1MAPK1EPHX2 | |
| SCHEMBL3930520 | 0.85 | PRKCI (0.57) | ALDH1A1KDM4ENPC1MAPK1PRMT6 | |
| SCHEMBL12869883 | 0.85 | KDM4E (0.59) | ALDH1A1KDM4ENPC1MAPK1CYP11B1 | |
| SCHEMBL29466814 | 0.83 | NAPRT (0.62) | ALDH1A1KDM4ENPC1MAPK1CYP19A1 | |
| SCHEMBL178130 | 0.83 | NAPRT (0.62) | ALDH1A1KDM4ENPC1MAPK1CYP19A1 | |
| SCHEMBL3932055 | 0.82 | ALDH1A1 (0.60) | ALDH1A1KDM4ENPC1MAPK1CYP11B1 | |
| SCHEMBL3667115 | 0.82 | CYP11B1 (0.54) | ALDH1A1KDM4ENPC1MAPK1EPHX2 | |
| SCHEMBL3941960 | 0.82 | NAPRT (0.67) | ALDH1A1KDM4EEPHX2PRMT6SYK | |
| SCHEMBL1929079 | 0.82 | SLC7A5 (0.57) | ALDH1A1KDM4ENPC1SYKSLC7A5 | |
| Ammonia Solution, Strong SCHEMBL27841922 | 0.82 | NAPRT (0.61) | ALDH1A1KDM4ENPC1MAPK1CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101490001-A | Substituted phenylacetic acids as DP-2 antagonists | ICOS CORP (US) | 2009-07-22 | — | — | CN | disclosed |
| EP-2044017-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2009-04-08 | — | — | EP | disclosed |
| WO-2007146838-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2007-12-21 | — | — | WO | disclosed |
| WO-2007146838-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2007-12-21 | — | — | WO | disclosed |