Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.60 |
| ▸ | NPC1 | O15118 | 3/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | GFER | P55789 | 1/20 | 0.52 |
| ▸ | THRA | P10827 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.45 |
| ▸ | RELA | Q04206 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.44 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.44 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3941801 | 0.86 | ALDH1A1 (0.58) | ALDH1A1NPC1KDM4EMAPK1THRA | |
| SCHEMBL9202609 | 0.85 | ALDH1A1 (0.59) | ALDH1A1NPC1GAAGFERTHRA | |
| SCHEMBL3933089 | 0.82 | ALDH1A1 (0.60) | ALDH1A1NPC1KDM4EMAPK1CYP11B1 | |
| SCHEMBL12869883 | 0.82 | KDM4E (0.59) | ALDH1A1NPC1KDM4EMAPK1CYP11B1 | |
| SCHEMBL14768426 | 0.81 | GAA (0.70) | ALDH1A1NPC1KDM4EGAAGFER | |
| SCHEMBL3938619 | 0.80 | ALDH1A1 (0.52) | ALDH1A1NPC1KDM4EMAPK1THRA | |
| SCHEMBL5992324 | 0.79 | MAPT (0.52) | ALDH1A1NPC1THRATHRBRAB9A | |
| SCHEMBL8200563 | 0.78 | ALDH1A1 (0.51) | ALDH1A1NPC1GAAGFERTHRA | |
| SCHEMBL8201063 | 0.78 | ALDH1A1 (0.51) | ALDH1A1NPC1GAAGFERTHRA | |
| SCHEMBL18269502 | 0.77 | ALDH1A1 (0.54) | ALDH1A1NPC1KDM4EGAAGFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044017-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2009-04-08 | — | — | EP | disclosed |
| WO-2007146838-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2007-12-21 | — | — | WO | disclosed |
| WO-2007146838-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2007-12-21 | — | — | WO | disclosed |