Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 6/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 4/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | HTR2B | P41595 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3951473 | 0.89 | USP30 (0.35) | CCR5L3MBTL3ATMUSP30 | |
| SCHEMBL10205080 | 0.85 | VNN1 (0.38) | CCR5PDK2L3MBTL3 | |
| SCHEMBL16430680 | 0.83 | PDK2 (0.35) | CCR5PDK2HRH3L3MBTL3KCNH2 | |
| SCHEMBL17589231 | 0.83 | PDK2 (0.33) | CCR5PDK2L3MBTL3ATMUSP30 | |
| SCHEMBL17589228 | 0.83 | DPP4 (0.36) | CCR5PDK2L3MBTL3ATMALDH1A1 | |
| SCHEMBL10205061 | 0.81 | VNN1 (0.40) | CCR5PDK2KCNH2 | |
| SCHEMBL17589227 | 0.80 | CCR5 (0.38) | CCR5PDK2L3MBTL3USP30NPY5R | |
| SCHEMBL16219518 | 0.80 | PDK2 (0.36) | CCR5PDK2L3MBTL3KCNH2USP30 | |
| SCHEMBL10205070 | 0.80 | CCR5 (0.39) | CCR5KCNH2DRD2SIGMAR1ALDH1A1 | |
| SCHEMBL14828851 | 0.80 | ATM (0.41) | ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107488146-B | Isocorydine derivative and preparation method and application thereof | 中国科学院兰州化学物理研究所 | 2020-05-22 | — | — | CN | disclosed |
| EP-1868611-A4 | NOVEL COMPOUNDS | GLAXO GROUP LTD (GB) | 2009-05-27 | — | — | EP | disclosed |
| EP-2043744-A2 | CHEMICAL COMPOUNDS | SmithKline Beecham Corporation (US) | 2009-04-08 | — | — | EP | disclosed |
| WO-2008008895-A1 | GPR119 AGONISTS FOR THE TREATMENT OF DIABETES AND RELATED DISORDERS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-01-17 | — | — | WO | disclosed |
| WO-2008008887-A2 | GPR119 AGONISTS FOR TREATING METABOLIC DISORDERS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-01-17 | — | — | WO | disclosed |
| WO-2006104915-A9 | 8-PHENYL-7,8-DIHYDROPYRIDO[2,3-d]PYRIMIDIN-7-ONES AND THEIR USE AS PHARMACEUTICALS | GLAXO GROUP LTD (GB) | 2008-01-03 | — | — | WO | disclosed |
| EP-1868611-A2 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2007-12-26 | — | — | EP | disclosed |
| WO-2007016610-A2 | ANTIBACTERIAL AGENTS | GLAXO GROUP LIMITED (GB) | 2007-02-08 | — | — | WO | disclosed |
| WO-2006104915-A2 | 8-PHENYL-7,8-DIHYDROPYRIDO[2,3-d]PYRIMIDIN-7-ONES AND THEIR USE AS PHARMACEUTICALS | GLAXO GROUP LIMITED (GB) | 2006-10-05 | — | — | WO | disclosed |