Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 7/20 | 0.76 |
| ▸ | BRAF | P15056 | 5/20 | 0.65 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.62 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.62 |
| ▸ | NAMPT | P43490 | 2/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3935559 | 0.91 | BRAF (0.80) | CSF1RBRAFCYP11B2CYP11B1 | |
| SCHEMBL3941714 | 0.88 | BRAF (0.83) | CSF1RBRAF | |
| SCHEMBL3931994 | 0.88 | CSF1R (0.65) | CSF1RBRAFCYP11B2CYP11B1NAMPT | |
| SCHEMBL3932812 | 0.86 | CSF1R (1.00) | CSF1RBRAFCYP11B2 | |
| SCHEMBL3931806 | 0.85 | BRAF (0.78) | CSF1RBRAF | |
| SCHEMBL3939077 | 0.85 | BRAF (0.66) | CSF1RBRAFCYP11B2CYP11B1TDP1 | |
| SCHEMBL3931363 | 0.84 | CSF1R (0.80) | CSF1RBRAFCYP11B2CYP11B1 | |
| SCHEMBL3938937 | 0.84 | CSF1R (0.86) | CSF1RBRAF | |
| SCHEMBL3936478 | 0.83 | CSF1R (0.81) | CSF1RBRAFCYP11B2CYP11B1 | |
| M-Xylene SCHEMBL27720422 | 0.82 | BRAF (0.58) | CSF1RBRAFCYP11B2CYP11B1NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831198-B1 | PYRIDINE CARBOXAMIDE DERIVATIVES FOR USE AS ANTICANCER AGENTS | ASTRAZENECA AB (SE) | 2009-04-08 | — | — | EP | disclosed |
| CN-101128454-A | Pyridine carboxamide derivatives for use as anticancer agents | ASTRAZENECA AB (SE) | 2008-02-20 | — | — | CN | disclosed |