Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.65 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | HPGD | P15428 | 3/20 | 0.53 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.48 |
| ▸ | RAD52 | P43351 | 1/20 | 0.45 |
| ▸ | PPARD | Q03181 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2926409 | 0.95 | CYP1A2 (0.67) | TMEM97SIGMAR1CYP1A2ALDH1A1KDM4E | |
| SCHEMBL4077983 | 0.84 | TMEM97 (0.58) | TMEM97SIGMAR1CYP1A2ALDH1A1KDM4E | |
| SCHEMBL26838419 | 0.82 | TMEM97 (0.59) | TMEM97SIGMAR1CYP1A2ALDH1A1KDM4E | |
| SCHEMBL30231342 | 0.81 | ACKR3 (0.69) | TMEM97SIGMAR1CYP1A2ALDH1A1KDM4E | |
| SCHEMBL2823242 | 0.80 | CYP1A2 (0.68) | TMEM97SIGMAR1CYP1A2ALDH1A1KDM4E | |
| SCHEMBL12121026 | 0.80 | HTT (0.74) | TMEM97SIGMAR1CYP1A2ALDH1A1KDM4E | |
| SCHEMBL582871 | 0.79 | TMEM97 (0.57) | TMEM97SIGMAR1CYP1A2ALDH1A1KDM4E | |
| SCHEMBL18730432 | 0.79 | SIGMAR1 (1.00) | TMEM97SIGMAR1ACKR3 | |
| SCHEMBL17677968 | 0.79 | CYP1A2 (0.49) | TMEM97SIGMAR1CYP1A2ALDH1A1KDM4E | |
| SCHEMBL2993559 | 0.79 | HTT (0.56) | TMEM97SIGMAR1CYP1A2ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044058-A1 | CHEMICAL COMPOUNDS | AstraZeneca AB (SE) | 2009-04-08 | — | — | EP | disclosed |
| WO-2007148070-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2007-12-27 | — | — | WO | disclosed |