Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.58 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | PPARD | Q03181 | 1/20 | 0.46 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | ESRRG | P62508 | 1/20 | 0.43 |
| ▸ | FLT1 | P17948 | 1/20 | 0.42 |
| ▸ | FLT4 | P35916 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2921979 | 0.94 | TMEM97 (0.56) | TMEM97SIGMAR1KMT2ANPC1RAB9A | |
| SCHEMBL26838419 | 0.87 | TMEM97 (0.59) | TMEM97SIGMAR1KMT2ANPC1RAB9A | |
| SCHEMBL3934495 | 0.84 | TMEM97 (0.65) | TMEM97SIGMAR1KMT2ANPC1RAB9A | |
| SCHEMBL21333220 | 0.83 | HPGD (0.49) | TMEM97SIGMAR1KMT2ANPC1RAB9A | |
| SCHEMBL30285543 | 0.83 | HPGD (0.49) | TMEM97SIGMAR1KMT2ANPC1RAB9A | |
| SCHEMBL582871 | 0.81 | TMEM97 (0.57) | TMEM97SIGMAR1KMT2ANPC1RAB9A | |
| SCHEMBL4510569 | 0.80 | TMEM97 (0.58) | TMEM97SIGMAR1KMT2ANPC1RAB9A | |
| SCHEMBL24100547 | 0.79 | HPGD (0.66) | TMEM97SIGMAR1KMT2ANPC1RAB9A | |
| SCHEMBL582402 | 0.79 | TMEM97 (0.61) | TMEM97SIGMAR1KMT2ANPC1RAB9A | |
| SCHEMBL156346 | 0.79 | DGAT1 (0.68) | TMEM97SIGMAR1KMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044058-A1 | CHEMICAL COMPOUNDS | AstraZeneca AB (SE) | 2009-04-08 | — | — | EP | disclosed |
| WO-2007148070-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2007-12-27 | — | — | WO | disclosed |