Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 14/20 | 0.68 |
| ▸ | CSF1R | P07333 | 5/20 | 0.61 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.59 |
| ▸ | KIT | P10721 | 1/20 | 0.57 |
| ▸ | KDR | P35968 | 1/20 | 0.57 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9906904 | 0.88 | RAB9A (0.65) | CYP11B2NPC1 | |
| SCHEMBL3943800 | 0.83 | BRAF (0.80) | BRAFCSF1RCYP11B2 | |
| SCHEMBL27720411 | 0.81 | CYP11B2 (0.76) | BRAFCSF1RCYP11B2MEN1NPC1 | |
| SCHEMBL3942866 | 0.81 | BRAF (0.70) | BRAFCSF1RCYP11B2NPC1 | |
| SCHEMBL3935916 | 0.81 | BRAF (0.63) | BRAFCSF1RCYP11B2KITKDR | |
| SCHEMBL3941755 | 0.81 | BRAF (0.73) | BRAFCSF1RCYP11B2MEN1NPC1 | |
| SCHEMBL1276903 | 0.81 | BRAF (1.00) | BRAFCSF1RCYP11B2MEN1KMT2A | |
| SCHEMBL3941877 | 0.81 | BRAF (0.83) | BRAFCSF1RCYP11B2NPC1 | |
| SCHEMBL3937779 | 0.81 | BRAF (1.00) | BRAFCSF1RKITKDRMAPK14 | |
| SCHEMBL3937724 | 0.80 | CSF1R (0.83) | BRAFCSF1RCYP11B2KITKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831198-B1 | PYRIDINE CARBOXAMIDE DERIVATIVES FOR USE AS ANTICANCER AGENTS | ASTRAZENECA AB (SE) | 2009-04-08 | — | — | EP | disclosed |
| CN-101128454-A | Pyridine carboxamide derivatives for use as anticancer agents | ASTRAZENECA AB (SE) | 2008-02-20 | — | — | CN | disclosed |