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SCHEMBL3934937

SCHEMBL3934937

O=S(=O)(Cc1cccc(Cl)c1)N1CCc2c(ccnc2Nc2cnc3ccccc3c2)C1

nearest known ligand 0.77

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
▸ FAAH O00519 12/20 0.77
▸ IGF1R P08069 1/20 0.43
▸ ALDH1A1 P00352 1/20 0.38
▸ LMNA P02545 1/20 0.38
▸ MAPK1 P28482 1/20 0.38
▸ HTT P42858 1/20 0.38
▸ HTR7 P34969 1/20 0.37
▸ HTR6 P50406 1/20 0.37
▸ ALPL P05186 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3933728 0.93 FAAH (0.79) FAAHIGF1RALDH1A1LMNAMAPK1
SCHEMBL3931969 0.92 FAAH (0.79) FAAHALDH1A1LMNAMAPK1HTT
SCHEMBL3939496 0.92 FAAH (0.78) FAAHALDH1A1LMNAMAPK1HTT
SCHEMBL3931347 0.88 FAAH (0.69) FAAHALDH1A1LMNAMAPK1HTT
SCHEMBL3933874 0.87 FAAH (0.75) FAAHALDH1A1LMNAMAPK1HTT
SCHEMBL3933565 0.87 FAAH (1.00) FAAHALDH1A1LMNAMAPK1HTT
SCHEMBL3935806 0.86 FAAH (0.78) FAAHALDH1A1LMNAMAPK1HTT
SCHEMBL3939612 0.86 FAAH (0.83) FAAHIGF1RALDH1A1LMNAMAPK1
SCHEMBL3938179 0.85 FAAH (0.71) FAAHALDH1A1LMNAMAPK1HTT
SCHEMBL3932061 0.85 FAAH (0.73) FAAHALDH1A1LMNAMAPK1HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009011904-A1 COMPOUNDS USEFUL AS FAAH MODULATORS AND USES THEREOF RENOVIS, INC. (US) 2009-01-22 — — WO disclosed