Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.81 |
| ▸ | FAAH | O00519 | 1/20 | 0.78 |
| ▸ | MEN1 | O00255 | 5/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.68 |
| ▸ | POLB | P06746 | 2/20 | 0.68 |
| ▸ | THRB | P10828 | 1/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.66 |
| ▸ | GFER | P55789 | 1/20 | 0.66 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | GAA | P10253 | 3/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | GLA | P06280 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | XBP1 | P17861 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13381103 | 0.89 | MAPT (1.00) | MAPTFAAHMEN1KMT2APOLB | |
| SCHEMBL395281 | 0.88 | FAAH (0.83) | MAPTFAAHMEN1KMT2APOLB | |
| SCHEMBL393675 | 0.88 | FAAH (1.00) | MAPTFAAHMEN1KMT2APOLB | |
| SCHEMBL391199 | 0.86 | FAAH (0.76) | MAPTFAAHMEN1KMT2APOLB | |
| SCHEMBL393680 | 0.82 | FAAH (0.83) | MAPTFAAHMEN1KMT2APOLB | |
| SCHEMBL393982 | 0.82 | FAAH (0.65) | MAPTFAAHMEN1KMT2APOLB | |
| SCHEMBL394413 | 0.82 | FAAH (0.72) | MAPTFAAHMEN1KMT2APOLB | |
| SCHEMBL24863352 | 0.81 | FAAH (0.70) | MAPTFAAHMEN1KMT2APOLB | |
| SCHEMBL395724 | 0.80 | FAAH (0.76) | MAPTFAAHMEN1KMT2APOLB | |
| SCHEMBL393998 | 0.79 | FAAH (0.78) | MAPTFAAHMEN1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8101649-B2 | N-acylhydrazone derivatives useful as modulators of nicotinic acetylcholine receptors | NEUROSEARCH A/S (DK) | 2012-01-24 | — | — | US | disclosed |