SCHEMBL3935157

SCHEMBL3935157

C[Si](C)(C)CCOCn1cc2cc(F)cc(CCO)c2n1

nearest known ligand 0.34

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
DGAT1 O75907 4/20 0.33
KLKB1 P03952 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3936612 0.87 DGAT1 (0.30) DGAT1
SCHEMBL3926529 0.86 IDO1 (0.36) DGAT1
SCHEMBL3925961 0.86 MEN1 (0.30) DGAT1
SCHEMBL3923559 0.82
SCHEMBL2428726 0.79 DGAT1 (0.33) DGAT1
SCHEMBL2425022 0.78 DGAT1 (0.34) DGAT1
SCHEMBL2426288 0.77 NPC1 (0.32) DGAT1KLKB1
SCHEMBL3928026 0.75 DGAT1 (0.36) DGAT1
SCHEMBL3925801 0.74 DGAT1 (0.32) DGAT1
SCHEMBL25200103 0.74 DGAT1 (0.43) DGAT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009009411-A1 SUBSTITUTED HETEROCYCLIC ETHERS AND THEIR USE IN CNS DISORDERS BRISTOL-MYERS SQUIBB COMPANY (US) 2009-01-15 WO disclosed