Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | GLS | O94925 | 5/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2801719 | 0.91 | KDM4E (0.56) | MEN1KMT2AMAPTALDH1A1LMNA | |
| SCHEMBL955030 | 0.85 | MEN1 (0.55) | MEN1KMT2AMAPTALDH1A1LMNA | |
| SCHEMBL4442926 | 0.76 | CDK2 (0.44) | MEN1KMT2AMAPTALDH1A1LMNA | |
| SCHEMBL3940057 | 0.73 | ALDH1A1 (0.46) | MEN1KMT2AMAPTALDH1A1LMNA | |
| SCHEMBL4450271 | 0.73 | HDAC1 (0.53) | MEN1KMT2AMAPTALDH1A1TSHR | |
| SCHEMBL3938054 | 0.72 | ALDH1A1 (0.53) | MEN1KMT2AMAPTALDH1A1LMNA | |
| SCHEMBL3939511 | 0.70 | LMNA (0.48) | MEN1KMT2AMAPTALDH1A1LMNA | |
| SCHEMBL3937668 | 0.70 | ATM (0.55) | ALDH1A1LMNAHTTKDM4ERXFP1 | |
| SCHEMBL3936265 | 0.70 | KMT2A (0.47) | MEN1KMT2AMAPTTSHRTP53 | |
| SCHEMBL2930131 | 0.70 | MAPT (0.55) | MEN1KMT2AMAPTALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049106-A2 | PHARMACEUTICAL COMBINATIONS | Astex Therapeutics Limited (GB) | 2009-04-22 | — | — | EP | disclosed |
| EP-2046330-A2 | PHARMACEUTICAL COMBINATIONS | Astex Therapeutics Limited (GB) | 2009-04-15 | — | — | EP | disclosed |
| WO-2008007122-A2 | COMBINATIONS OF PYRAZOLE DERIVATIVES FOR THE INHIBITION OF CDKS AND GSK'S | ASTEX THERAPEUTICS LIMITED (GB) | 2008-01-17 | — | — | WO | disclosed |
| WO-2008007113-A2 | PHARMACEUTICAL COMBINATIONS | ASTEX THERAPEUTICS LIMITED (GB) | 2008-01-17 | — | — | WO | disclosed |