Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.45 |
| ▸ | BCL9 | O00512 | 5/20 | 0.44 |
| ▸ | CTNNB1 | P35222 | 5/20 | 0.44 |
| ▸ | FAAH | O00519 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3932020 | 0.89 | ALDH1A1 (0.50) | KMT2AALDH1A1HSP90AA1BCL9CTNNB1 | |
| SCHEMBL3940272 | 0.89 | ALDH1A1 (0.50) | KMT2AALDH1A1BCL9CTNNB1MEN1 | |
| SCHEMBL3941453 | 0.89 | BCL9 (0.47) | KMT2AALDH1A1BCL9CTNNB1MEN1 | |
| SCHEMBL3935829 | 0.88 | NPC1 (0.53) | KMT2AALDH1A1BCL9CTNNB1MEN1 | |
| SCHEMBL3941513 | 0.88 | SMN1; SMN2 (0.48) | KMT2ABCL9CTNNB1MEN1LMNA | |
| SCHEMBL3936472 | 0.88 | TP53 (0.48) | KMT2AALDH1A1BCL9CTNNB1MEN1 | |
| SCHEMBL3933582 | 0.88 | GAA (0.49) | KMT2AALDH1A1BCL9CTNNB1MEN1 | |
| SCHEMBL3928444 | 0.86 | BCL9 (0.55) | KMT2AALDH1A1BCL9CTNNB1MEN1 | |
| SCHEMBL3930533 | 0.86 | BCL9 (0.50) | KMT2AALDH1A1BCL9CTNNB1MEN1 | |
| SCHEMBL3932848 | 0.85 | BCL9 (0.47) | ALDH1A1BCL9CTNNB1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044017-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2009-04-08 | — | — | EP | disclosed |
| WO-2007146838-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2007-12-21 | — | — | WO | disclosed |