Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
| ▸ | GPR132 | Q9UNW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3932476 | 0.76 | TACR1 (0.43) | — | |
| SCHEMBL1630838 | 0.76 | CYP11B1 (0.40) | — | |
| SCHEMBL1314001 | 0.72 | AGXT (0.42) | — | |
| SCHEMBL14449078 | 0.72 | HTR1A (0.43) | GPR132 | |
| SCHEMBL7617913 | 0.70 | LMNA (0.46) | GPR132 | |
| SCHEMBL29203398 | 0.70 | ACSS2 (0.35) | — | |
| SCHEMBL30240876 | 0.70 | ACSS2 (0.35) | — | |
| SCHEMBL31124766 | 0.70 | TSHR (0.35) | ESR1ESR2 | |
| SCHEMBL31160327 | 0.70 | TOP2A (0.43) | — | |
| SCHEMBL31226339 | 0.70 | HTR2C (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831198-B1 | PYRIDINE CARBOXAMIDE DERIVATIVES FOR USE AS ANTICANCER AGENTS | ASTRAZENECA AB (SE) | 2009-04-08 | — | — | EP | disclosed |
| WO-2006067445-A2 | CSF-1R KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2006-06-29 | — | — | WO | disclosed |