Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 2/20 | 0.54 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.52 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.48 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.48 |
| ▸ | PPARA | Q07869 | 2/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | CTSS | P25774 | 4/20 | 0.47 |
| ▸ | CTSK | P43235 | 4/20 | 0.47 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3936484 | 1.00 | ACE (0.54) | ACEITGB3ITGA2BMAPK1KMT2A | |
| SCHEMBL3936455 | 1.00 | ACE (0.54) | ACEITGB3ITGA2BMAPK1KMT2A | |
| SCHEMBL5151943 | 1.00 | ACE (0.54) | ACEITGB3ITGA2BMAPK1KMT2A | |
| SCHEMBL14542443 | 0.91 | ACE (0.48) | ACEITGB3ITGA2BMAPK1KMT2A | |
| SCHEMBL3936988 | 0.84 | LMNA (0.54) | ACEITGB3ITGA2BKMT2AITGA4 | |
| SCHEMBL14542560 | 0.84 | KMT2A (0.46) | ACEKMT2AL3MBTL1ATMCTSS | |
| SCHEMBL3440409 | 0.79 | L3MBTL1 (0.52) | KMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL5234659 | 0.79 | CACNA1B (0.47) | ACEKMT2AL3MBTL1ALDH1A1CACNA1B | |
| SCHEMBL7228964 | 0.79 | ACE (0.55) | ACEITGB3ITGA2BMAPK1KMT2A | |
| SCHEMBL181849 | 0.79 | PPARA (0.65) | ACEITGB3ITGA2BITGA4ITGB7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1945621-B1 | PROCESS TO PREPARE AMINO ACID DERIVATIVES | REDDY S LAB EU LTD DR (GB) | 2009-04-15 | — | — | EP | disclosed |
| US-7157454-B2 | Derivatives of n-(arylsulfonyl)beta-aminoacids comprising a substituted aminomethyl group, the preparation method thereof and the pharmaceutical compositions containing same | SANOFI-AVENTIS (FR) | 2007-01-02 | — | — | US | disclosed |
| US-20040116353-A1 | Derivatives of n-(arylsulfonyl)beta-aminoacids comprising a substituted aminomethyl group, the preparation method thereof and the pharmaceutical compositions containing same | SANOFI (FR) | 2004-06-17 | — | — | US | disclosed |