Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | G6PD | P11413 | 1/20 | 0.46 |
| ▸ | CASP7 | P55210 | 1/20 | 0.46 |
| ▸ | CASP6 | P55212 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CTSD | P07339 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7546194 | 0.96 | ALDH1A1 (0.60) | ALDH1A1KMT2APTK2BMEN1G6PD | |
| SCHEMBL7773567 | 0.86 | KMT2A (0.50) | ALDH1A1KMT2APTK2BMEN1G6PD | |
| SCHEMBL9348401 | 0.86 | G6PD (0.47) | ALDH1A1KMT2APTK2BG6PDCASP7 | |
| SCHEMBL25438784 | 0.84 | KMT2A (0.54) | ALDH1A1KMT2APTK2BMEN1G6PD | |
| SCHEMBL1505142 | 0.83 | ALDH1A1 (0.74) | ALDH1A1KMT2APTK2BMEN1KDM4E | |
| SCHEMBL23352277 | 0.83 | CYP1A2 (0.44) | KDM4ELMNASMN1; SMN2CYP2C9IKBKB | |
| SCHEMBL28277529 | 0.83 | ALDH1A1 (0.54) | ALDH1A1KMT2APTK2BMEN1KDM4E | |
| SCHEMBL1320478 | 0.82 | L3MBTL1 (0.50) | ALDH1A1KMT2APTK2BMEN1G6PD | |
| Hydrochloric Acid SCHEMBL29021559 | 0.81 | ALDH1A1 (0.50) | ALDH1A1KMT2AKDM4ELMNASMN1; SMN2 | |
| SCHEMBL148830 | 0.80 | G6PD (0.60) | ALDH1A1KMT2AG6PDCASP7CASP6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2046793-A2 | FUSED PYRIMIDO COMPOUNDS | AstraZeneca AB (SE) | 2009-04-15 | — | — | EP | disclosed |
| WO-2008003958-A2 | FUSED PYRIMIDO COMPOUNDS | ASTRAZENECA AB (SE) | 2008-01-10 | — | — | WO | disclosed |