Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | PNMT | P11086 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.31 |
| ▸ | HTR2B | P41595 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
| ▸ | DRD4 | P21917 | 1/20 | 0.30 |
| ▸ | DRD3 | P35462 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL30460527 | 0.82 | PNMT (0.39) | PNMTNPC1RAB9AHTR7HTR2B | |
| Hydrochloric Acid SCHEMBL715076 | 0.80 | PNMT (0.39) | EGFRPNMTNPC1RAB9AHTR7 | |
| Hydrochloric Acid SCHEMBL29597181 | 0.80 | PNMT (0.39) | EGFRPNMTNPC1RAB9AHTR7 | |
| Hydrochloric Acid SCHEMBL30460528 | 0.79 | PNMT (0.36) | PNMTNPC1RAB9AHTR7HTR2B | |
| SCHEMBL6672847 | 0.76 | PNMT (0.49) | EGFRPNMTNPC1RAB9AHTR7 | |
| SCHEMBL29617348 | 0.76 | PNMT (0.49) | EGFRPNMTNPC1RAB9AHTR7 | |
| Hydrochloric Acid SCHEMBL29597205 | 0.76 | PNMT (0.36) | EGFRPNMTNPC1RAB9AHTR7 | |
| Hydrochloric Acid SCHEMBL6558717 | 0.74 | PNMT (0.46) | EGFRPNMTNPC1RAB9AHTR7 | |
| SCHEMBL6675580 | 0.73 | PNMT (0.49) | EGFRPNMTNPC1RAB9AHTR7 | |
| Hydrochloric Acid SCHEMBL395592 | 0.73 | PNMT (0.52) | PNMTNPC1RAB9AHTR7HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8431659-B2 | Prepolymerized catalyst for olefin polymerization, method of producing this prepolymerized catalyst and method of producing olefin polymer | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2013-04-30 | — | — | US | disclosed |
| US-20120095173-A1 | PREPOLYMERIZED CATALYST FOR OLEFIN POLYMERIZATION, METHOD OF PRODUCING THIS PREPOLYMERIZED CATALYST AND METHOD OF PRODUCING OLEFIN POLYMER | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2012-04-19 | — | — | US | disclosed |
| US-8101537-B2 | Prepolymerized catalyst for olefin polymerization, method of producing this prepolymerized catalyst and method of producing olefin polymer | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2012-01-24 | — | — | US | disclosed |
| US-20100280196-A1 | PREPOLYMERIZED CATALYST FOR OLEFIN POLYMERIZATION, METHOD OF PRODUCING THIS PREPOLYMERIZED CATALYST AND METHOD OF PRODUCING OLEFIN POLYMER | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2010-11-04 | — | — | US | disclosed |