Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 9/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 8/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 8/20 | 0.39 |
| ▸ | IKBKB | O14920 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.33 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.33 |
| ▸ | TACR1 | P25103 | 3/20 | 0.33 |
| ▸ | REN | P00797 | 1/20 | 0.33 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | MC4R | P32245 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3939710 | 0.91 | SLC6A2 (0.40) | SLC6A2SLC6A4SLC6A3IKBKBKCNH2 | |
| SCHEMBL3931492 | 0.91 | REN (0.41) | SLC6A2SLC6A4SLC6A3IKBKBKCNH2 | |
| SCHEMBL3939276 | 0.90 | SLC6A2 (0.39) | SLC6A2SLC6A4SLC6A3IKBKBHTR6 | |
| SCHEMBL3927956 | 0.89 | SLC6A4 (0.39) | SLC6A2SLC6A4SLC6A3IKBKBHTR6 | |
| SCHEMBL3939023 | 0.87 | SLC6A2 (0.37) | SLC6A2SLC6A4SLC6A3IKBKBKCNH2 | |
| SCHEMBL3936556 | 0.86 | IKBKB (0.36) | SLC6A2SLC6A4SLC6A3IKBKBHTR6 | |
| SCHEMBL3928975 | 0.84 | REN (0.44) | SLC6A2SLC6A4SLC6A3IKBKBREN | |
| SCHEMBL3939671 | 0.83 | REN (0.45) | SLC6A2SLC6A4SLC6A3IKBKBREN | |
| SCHEMBL3929666 | 0.82 | REN (0.40) | SLC6A2SLC6A4SLC6A3IKBKBREN | |
| SCHEMBL3938205 | 0.80 | REN (0.39) | SLC6A2SLC6A4SLC6A3REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044054-A2 | PYRIMIDINE AND QUINAZOLINE DERIVATIVES AS MODULATORS OF SOMATOSTATINE RECEPTOR ACTIVITY | F. Hoffmann-Roche AG (CH) | 2009-04-08 | — | — | EP | disclosed |
| WO-2008000692-A2 | PYRIMIDINE AND QUINAZOLINE DERIVATIVES AS MODULATORS OF SOMATOSTATINE RECEPTOR ACTIVITY | F. HOFFMANN-LA ROCHE AG (CH) | 2008-01-03 | — | — | WO | disclosed |