Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 7/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 7/20 | 0.40 |
| ▸ | IKBKB | O14920 | 5/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | SSTR5 | P35346 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | REN | P00797 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3931492 | 0.93 | REN (0.41) | SLC6A2SLC6A4SLC6A3IKBKBKCNH2 | |
| SCHEMBL3939276 | 0.92 | SLC6A2 (0.39) | SLC6A2SLC6A4SLC6A3IKBKBKCNH2 | |
| SCHEMBL3927956 | 0.91 | SLC6A4 (0.39) | SLC6A2SLC6A4SLC6A3IKBKBKCNH2 | |
| SCHEMBL3937186 | 0.91 | SLC6A2 (0.39) | SLC6A2SLC6A4SLC6A3IKBKBKCNH2 | |
| SCHEMBL3939023 | 0.88 | SLC6A2 (0.37) | SLC6A2SLC6A4SLC6A3IKBKBKCNH2 | |
| SCHEMBL3936556 | 0.88 | IKBKB (0.36) | SLC6A2SLC6A4SLC6A3IKBKBKCNH2 | |
| SCHEMBL3928975 | 0.85 | REN (0.44) | SLC6A2SLC6A4SLC6A3IKBKBSSTR5 | |
| SCHEMBL3939671 | 0.84 | REN (0.45) | SLC6A2SLC6A4SLC6A3IKBKBKDM4E | |
| SCHEMBL3938205 | 0.84 | REN (0.39) | SLC6A2SLC6A4SLC6A3ALDH1A1KDM4E | |
| SCHEMBL3929666 | 0.83 | REN (0.40) | SLC6A2SLC6A4SLC6A3IKBKBSSTR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044054-A2 | PYRIMIDINE AND QUINAZOLINE DERIVATIVES AS MODULATORS OF SOMATOSTATINE RECEPTOR ACTIVITY | F. Hoffmann-Roche AG (CH) | 2009-04-08 | — | — | EP | disclosed |
| WO-2008000692-A2 | PYRIMIDINE AND QUINAZOLINE DERIVATIVES AS MODULATORS OF SOMATOSTATINE RECEPTOR ACTIVITY | F. HOFFMANN-LA ROCHE AG (CH) | 2008-01-03 | — | — | WO | disclosed |