Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.69 |
| ▸ | MAPT | P10636 | 1/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | CASP1 | P29466 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | THRB | P10828 | 1/20 | 0.59 |
| ▸ | RECQL | P46063 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | FLT1 | P17948 | 4/20 | 0.57 |
| ▸ | FLT4 | P35916 | 4/20 | 0.57 |
| ▸ | KDR | P35968 | 4/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | JAK2 | O60674 | 1/20 | 0.57 |
| ▸ | JAK1 | P23458 | 1/20 | 0.57 |
| ▸ | TYK2 | P29597 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11419345 | 0.85 | ALDH1A1 (0.77) | KDM4EMAPTSMN1; SMN2TSHRCASP1 | |
| SCHEMBL6790469 | 0.83 | KDM4E (0.69) | KDM4EMAPTSMN1; SMN2TSHRCASP1 | |
| SCHEMBL9782403 | 0.82 | KDM4E (0.62) | KDM4EMAPTSMN1; SMN2TSHRCASP1 | |
| SCHEMBL1127878 | 0.82 | KDM4E (1.00) | KDM4EMAPTSMN1; SMN2TSHRCASP1 | |
| SCHEMBL6971076 | 0.82 | KDM4E (0.67) | KDM4EMAPTSMN1; SMN2TSHRCASP1 | |
| SCHEMBL4154496 | 0.82 | KDM4E (0.67) | KDM4EMAPTSMN1; SMN2TSHRCASP1 | |
| SCHEMBL29833777 | 0.82 | KDM4E (0.67) | KDM4EMAPTSMN1; SMN2TSHRCASP1 | |
| Hydrochloric Acid SCHEMBL21381943 | 0.80 | KDM4E (0.96) | KDM4EMAPTSMN1; SMN2TSHRCASP1 | |
| SCHEMBL13479741 | 0.80 | MAPT (0.64) | KDM4EMAPTSMN1; SMN2TSHRCASP1 | |
| SCHEMBL1514676 | 0.79 | KDM4E (0.68) | KDM4EMAPTSMN1; SMN2TSHRCASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1931335-B1 | HEXAHYDRO CYCLOOCTYL PYRAZOLE CANNABINOID MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2010-02-24 | — | — | EP | claimed |
| EP-1863479-B1 | TETRAHYDROTHIOPYRANO PYRAZOLE CANNABINOID MODULATORS CROSS REFERENCE TO RELATED APPLICATIONS | JANSSEN PHARMACEUTICA NV (BE) | 2008-12-10 | — | — | EP | claimed |
| US-8101592-B2 | Hexahydro-cyclooctyl pyrazole cannabinoid modulators | JANSSEN PHARMACEUTICA N.V. (BG) | 2012-01-24 | — | — | US | disclosed |
| EP-1863479-A1 | TETRAHYDROTHIOPYRANO PYRAZOLE CANNABINOID MODULATORS CROSS REFERENCE TO RELATED APPLICATIONS | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-12-12 | — | — | EP | disclosed |
| WO-2006107561-A1 | TETRAHYDROTHIOPYRANO PYRAZOLE CANNABINOID MODULATORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2006-10-12 | — | — | WO | disclosed |
| US-20060223798-A1 | Tetrahydrothiopyrano pyrazole cannabinoid modulators | JANSSEN PHARMACEUTICA NV (BE) | 2006-10-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060223798-A1 | Tetrahydrothiopyrano pyrazole cannabinoid modulators | CNR1, CNR2, GPR18 | KDM4E 2507/4885MAPT 1971/4885SMN1; SMN2 3875/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.