Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 12/20 | 0.84 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.62 |
| ▸ | RAB9A | P51151 | 1/20 | 0.61 |
| ▸ | CSF1R | P07333 | 3/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | PKM | P14618 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13162010 | 0.93 | BRAF (0.71) | BRAFCYP11B2POLBKMT2ARAB9A | |
| SCHEMBL3936918 | 0.91 | BRAF (1.00) | BRAFPOLBKMT2ARAB9ACSF1R | |
| SCHEMBL13162340 | 0.91 | BRAF (0.79) | BRAFCYP11B2POLBKMT2ARAB9A | |
| SCHEMBL3944209 | 0.90 | CSF1R (0.74) | BRAFCYP11B2POLBKMT2ARAB9A | |
| SCHEMBL3942646 | 0.87 | BRAF (0.83) | BRAFRAB9ACSF1RALDH1A1 | |
| SCHEMBL3933426 | 0.87 | BRAF (0.84) | BRAFPOLBKMT2ARAB9ACSF1R | |
| SCHEMBL3941843 | 0.83 | BRAF (0.77) | BRAFCSF1R | |
| SCHEMBL27699790 | 0.83 | LMNA (0.79) | BRAFCSF1RALDH1A1 | |
| SCHEMBL3943800 | 0.82 | BRAF (0.80) | BRAFCYP11B2CSF1R | |
| SCHEMBL3941536 | 0.82 | BRAF (0.79) | BRAFRAB9ACSF1RALDH1A1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831198-B1 | PYRIDINE CARBOXAMIDE DERIVATIVES FOR USE AS ANTICANCER AGENTS | ASTRAZENECA AB (SE) | 2009-04-08 | — | — | EP | disclosed |