Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | CCR5 | P51681 | 5/20 | 0.51 |
| ▸ | LSS | P48449 | 1/20 | 0.48 |
| ▸ | KCNT1 | Q5JUK3 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3934199 | 0.92 | KDM4E (0.54) | PTGDR2ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL3928436 | 0.91 | PTGDR2 (0.48) | PTGDR2ALDH1A1SMN1; SMN2LMNAPOLB | |
| SCHEMBL3928788 | 0.90 | PTGDR2 (0.63) | PTGDR2ALDH1A1SMN1; SMN2LMNAPOLB | |
| SCHEMBL3939227 | 0.89 | ALDH1A1 (0.49) | PTGDR2ALDH1A1SMN1; SMN2GAATSHR | |
| SCHEMBL3928218 | 0.88 | ALDH1A1 (0.51) | PTGDR2ALDH1A1SMN1; SMN2LMNAPOLB | |
| SCHEMBL3937733 | 0.88 | ALDH1A1 (0.52) | ALDH1A1SMN1; SMN2LMNAPOLBMAPK1 | |
| SCHEMBL3928439 | 0.88 | ALDH1A1 (0.63) | PTGDR2ALDH1A1SMN1; SMN2LMNAPOLB | |
| SCHEMBL3929256 | 0.87 | PTGDR2 (0.58) | PTGDR2ALDH1A1SMN1; SMN2LMNAPOLB | |
| SCHEMBL3937820 | 0.87 | PTGDR2 (0.58) | PTGDR2ALDH1A1SMN1; SMN2LMNAPOLB | |
| SCHEMBL3927277 | 0.86 | PTGDR2 (0.69) | PTGDR2ALDH1A1CCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044044-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2009-04-08 | — | — | EP | disclosed |
| WO-2007143745-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2007-12-13 | — | — | WO | disclosed |