Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.47 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.44 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.44 |
| ▸ | PDE5A | O76074 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3541959 | 1.00 | POLB (0.47) | POLBSIRT6USP30ALDH1A1KMT2A | |
| SCHEMBL736393 | 0.93 | SIRT6 (0.52) | POLBSIRT6ALDH1A1KMT2ALMNA | |
| SCHEMBL15880759 | 0.91 | SIRT6 (0.48) | POLBSIRT6ALDH1A1KMT2ALMNA | |
| SCHEMBL3544241 | 0.84 | ALDH1A1 (0.61) | POLBALDH1A1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL3538444 | 0.84 | MAPT (0.57) | POLBALDH1A1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL9964597 | 0.83 | AURKA (0.51) | MCHR1AURKAAURKB | |
| SCHEMBL13175736 | 0.82 | HTR4 (0.54) | USP30MCHR1AURKAAURKB | |
| SCHEMBL3544670 | 0.82 | HTR4 (0.54) | USP30MCHR1AURKAAURKB | |
| SCHEMBL736430 | 0.82 | ALDH1A1 (0.53) | POLBALDH1A1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL13846090 | 0.82 | HTR4 (0.54) | USP30MCHR1AURKAAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2046793-A2 | FUSED PYRIMIDO COMPOUNDS | AstraZeneca AB (SE) | 2009-04-15 | — | — | EP | disclosed |
| WO-2008003958-A2 | FUSED PYRIMIDO COMPOUNDS | ASTRAZENECA AB (SE) | 2008-01-10 | — | — | WO | disclosed |