Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APLNR | P35414 | 2/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.32 |
| ▸ | BRS3 | P32247 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 2/20 | 0.32 |
| ▸ | JAK3 | P52333 | 2/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.32 |
| ▸ | HRH1 | P35367 | 1/20 | 0.32 |
| ▸ | DHFR | P00374 | 1/20 | 0.32 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1693712 | 0.85 | APLNR (0.42) | APLNRNTRK1JAK2KCNH2HRH1 | |
| Hydrochloric Acid SCHEMBL3938088 | 0.83 | APLNR (0.41) | APLNRNTRK1JAK2KCNH2HRH1 | |
| SCHEMBL3770922 | 0.82 | APLNR (0.45) | APLNRBRS3KCNH2HRH1 | |
| SCHEMBL3942632 | 0.82 | APLNR (0.43) | APLNR | |
| SCHEMBL25207618 | 0.76 | APLNR (0.42) | APLNR | |
| SCHEMBL6856792 | 0.76 | APLNR (0.46) | APLNRJAK2JAK3KCNH2HRH1 | |
| SCHEMBL1440342 | 0.75 | APLNR (0.45) | APLNRNTRK1KCNH2HRH1 | |
| SCHEMBL1440344 | 0.75 | APLNR (0.45) | APLNRNTRK1KCNH2HRH1 | |
| Hydrochloric Acid SCHEMBL3020024 | 0.74 | APLNR (0.44) | APLNRNTRK1KCNH2HRH1 | |
| Hydrochloric Acid SCHEMBL1439641 | 0.74 | APLNR (0.44) | APLNRNTRK1KCNH2HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009016410-A2 | CHEMICAL COMPOUNDS 831 | ASTRAZENECA AB (SE) | 2009-02-05 | — | — | WO | disclosed |