Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.43 |
| ▸ | LMNA | P02545 | 5/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MITF | O75030 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3937011 | 0.89 | MAPT (0.46) | SMN1; SMN2ALDH1A1LMNAMAPTKMT2A | |
| SCHEMBL3943794 | 0.86 | ALDH1A1 (0.42) | SMN1; SMN2ALDH1A1LMNAMAPTKMT2A | |
| SCHEMBL3940421 | 0.82 | MAPT (0.48) | SMN1; SMN2ALDH1A1LMNAMAPTKMT2A | |
| SCHEMBL3941625 | 0.80 | HPGD (0.49) | SMN1; SMN2ALDH1A1LMNAMAPTKMT2A | |
| SCHEMBL2062103 | 0.75 | SMN1; SMN2 (0.64) | SMN1; SMN2ALDH1A1LMNAMAPTKMT2A | |
| SCHEMBL25837923 | 0.75 | SMN1; SMN2 (0.64) | SMN1; SMN2ALDH1A1LMNAMAPTKMT2A | |
| SCHEMBL1496409 | 0.72 | SMN1; SMN2 (0.60) | SMN1; SMN2ALDH1A1LMNAMAPTKMT2A | |
| SCHEMBL18545802 | 0.72 | ALDH1A1 (0.52) | ALDH1A1LMNAMAPTKMT2AL3MBTL1 | |
| SCHEMBL30686809 | 0.71 | SMN1; SMN2 (0.49) | SMN1; SMN2ALDH1A1LMNAMAPTKMT2A | |
| SCHEMBL14567836 | 0.71 | SMN1; SMN2 (0.49) | SMN1; SMN2ALDH1A1LMNAMAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1673352-B1 | SULFOXIMINE-SUBSTITUTED PYRIMIDINES FOR USE AS CD AND/OR VEGF-INHIBITORS, THE PRODUCTION THEREOF AND THEIR USE AS DRUGS | BAYER SCHERING PHARMA AG (DE) | 2009-04-08 | — | — | EP | disclosed |