Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | CASP7 | P55210 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.38 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3942434 | 0.91 | ALOX5 (0.41) | ALOX5KMT2ASMN1; SMN2HPGDMAPK1 | |
| SCHEMBL3947763 | 0.90 | ALOX5 (0.43) | ALOX5KMT2ASMN1; SMN2MEN1LTB4R | |
| SCHEMBL3942200 | 0.90 | ALOX5 (0.43) | ALOX5KMT2ASMN1; SMN2MEN1CYP2C9 | |
| SCHEMBL3946482 | 0.89 | ALOX5 (0.39) | ALOX5KMT2AHPGDMAPK1LMNA | |
| SCHEMBL1383618 | 0.86 | ALOX5 (0.47) | ALOX5KMT2ASMN1; SMN2HPGDMAPK1 | |
| SCHEMBL3951537 | 0.85 | CASR (0.46) | ALOX5KMT2AHPGDMAPK1MEN1 | |
| SCHEMBL3947316 | 0.83 | CASR (0.41) | ALOX5KMT2ALMNAMEN1 | |
| SCHEMBL3944917 | 0.82 | BACE1 (0.41) | KMT2ASMN1; SMN2MAPK1HTTMEN1 | |
| SCHEMBL3951123 | 0.82 | BACE1 (0.41) | ALOX5KMT2AMEN1CYP1A2CYP3A4 | |
| SCHEMBL3942446 | 0.81 | CASR (0.41) | ALOX5LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1718632-B1 | PYRIMIDINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | SANOFI AVENTIS (FR) | 2009-04-22 | — | — | EP | claimed |