Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.44 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | CASP7 | P55210 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3943900 | 0.82 | CASP3 (0.39) | CASP3CASP7TAAR1 | |
| SCHEMBL956763 | 0.82 | BACE1 (0.40) | CASP3CASP7TAAR1 | |
| SCHEMBL7436508 | 0.78 | ALDH1A1 (0.46) | TDP1 | |
| SCHEMBL10695355 | 0.77 | KMT2A (0.45) | MTNR1AMTNR1BCASP3CASP7HPGD | |
| SCHEMBL3945233 | 0.76 | GLA (0.62) | POLB | |
| SCHEMBL3951320 | 0.75 | GLA (0.47) | MTNR1AMTNR1BCASP3CASP7TAAR1 | |
| SCHEMBL16861294 | 0.73 | MTNR1A (0.57) | MTNR1AMTNR1BCASP3CASP7TAAR1 | |
| SCHEMBL11159763 | 0.72 | GRIN2B (0.44) | MTNR1AMTNR1BCASP3CASP7HPGD | |
| SCHEMBL7331644 | 0.72 | MTNR1A (0.60) | MTNR1AMTNR1BCASP3CASP7TAAR1 | |
| SCHEMBL30800373 | 0.72 | MTNR1A (0.60) | MTNR1AMTNR1BCASP3CASP7TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009020457-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-02-12 | — | — | WO | disclosed |
| WO-2009020457-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-02-12 | — | — | WO | disclosed |
| EP-0777653-B1 | DIHYGROPYRIDINE DERIVATIVES AS BRADYKININ ANTAGONISTS | PFIZER (US) | 2001-08-22 | — | — | EP | disclosed |
| US-5859011-A | Dihydropyridine derivatives as bradykinin antagonist | PFIZER INC. (US) | 1999-01-12 | — | — | US | disclosed |
| EP-0777653-A1 | DIHYGROPYRIDINE DERIVATIVES AS BRADYKININ ANTAGONISTS | PFIZER INC. (US) | 1997-06-11 | — | — | EP | disclosed |
| WO-1996006083-A1 | 2-(PIPERAZINYL-1-CARBONYLMETHYL)-1,4-DIHYDROPYRIDINES AS BRADYKININ ANTAGONISTS | PFIZER PHARMACEUTICALS INC. (JP) | 1996-02-29 | — | — | WO | disclosed |
| WO-1996006082-A1 | DIHYDROPYRIDINE DERIVATIVES AS BRADYKININ ANTAGONISTS | PFIZER INC. (US) | 1996-02-29 | — | — | WO | disclosed |