Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.40 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.39 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.38 |
| ▸ | GHSR | Q92847 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31715477 | 0.90 | ALDH1A1 (0.49) | ALDH1A1LMNAMAPTMEN1KMT2A | |
| SCHEMBL2954985 | 0.84 | PRMT5 (0.42) | ALDH1A1HSD11B1KMT2APRMT5WDR77 | |
| SCHEMBL1150225 | 0.81 | ALDH1A1 (0.52) | ALDH1A1LMNAMAPTKMT2AMCL1 | |
| SCHEMBL9216185 | 0.80 | ALDH1A1 (0.49) | ALDH1A1LMNAMAPTPRMT5WDR77 | |
| SCHEMBL9215446 | 0.80 | ALDH1A1 (0.49) | ALDH1A1LMNAMAPTPRMT5WDR77 | |
| SCHEMBL9214380 | 0.80 | ALDH1A1 (0.49) | ALDH1A1LMNAMAPTPRMT5WDR77 | |
| SCHEMBL4924131 | 0.77 | LMNA (0.51) | ALDH1A1LMNAMAPTMEN1KMT2A | |
| SCHEMBL31207347 | 0.77 | ALDH1A1 (0.41) | ALDH1A1LMNAMAPTHSD11B1MEN1 | |
| SCHEMBL30794155 | 0.77 | ALDH1A1 (0.48) | ALDH1A1LMNAMAPTGPR119 | |
| SCHEMBL14815143 | 0.77 | CYP3A4 (0.50) | ALDH1A1LMNAHSD11B1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8101595-B2 | Antiviral indoles | Istituto di Ricerche di Biologia Molecolare P. Angletti SpA (IT) | 2012-01-24 | — | — | US | disclosed |
| US-7989438-B2 | Therapeutic compounds | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2011-08-02 | — | — | US | disclosed |