Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.42 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.42 |
| ▸ | EPHA2 | P29317 | 4/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.39 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.38 |
| ▸ | NR1D1 | P20393 | 2/20 | 0.38 |
| ▸ | MMP1 | P03956 | 2/20 | 0.38 |
| ▸ | MMP9 | P14780 | 2/20 | 0.38 |
| ▸ | MMP3 | P08254 | 1/20 | 0.38 |
| ▸ | MMP7 | P09237 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9214380 | 1.00 | ALDH1A1 (0.49) | ALDH1A1LMNAMAPTPRMT5WDR77 | |
| SCHEMBL9215446 | 1.00 | ALDH1A1 (0.49) | ALDH1A1LMNAMAPTPRMT5WDR77 | |
| SCHEMBL617821 | 0.88 | PDK1 (0.45) | ALDH1A1EPHA2ERBB2EPHB4GPR119 | |
| SCHEMBL617822 | 0.88 | PDK1 (0.45) | ALDH1A1EPHA2ERBB2EPHB4GPR119 | |
| SCHEMBL618014 | 0.88 | PDK1 (0.45) | ALDH1A1EPHA2ERBB2EPHB4GPR119 | |
| SCHEMBL7291444 | 0.87 | STS (0.49) | EPHA2ERBB2EPHB4GPR119NR1D1 | |
| SCHEMBL394196 | 0.80 | ALDH1A1 (0.49) | ALDH1A1LMNAMAPTPRMT5WDR77 | |
| SCHEMBL15416553 | 0.80 | USP2 (0.44) | ALDH1A1MAPTEPHA2ERBB2EPHB4 | |
| SCHEMBL31494035 | 0.80 | EPHA2 (0.42) | EPHA2ERBB2EPHB4GPR119MMP1 | |
| SCHEMBL1439374 | 0.79 | USP2 (0.46) | ALDH1A1MAPTEPHA2ERBB2EPHB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0411912-B1 | Coumarin derivatives, their preparation and their use in the treatment of cerebrovascular disorders | SANKYO CO (JP) | 1995-04-19 | — | — | EP | disclosed |
| EP-0411912-A2 | Coumarin derivatives, their preparation and their use in the treatment of cerebrovascular disorders | Sankyo Company Limited (JP) | 1991-02-06 | — | — | EP | disclosed |