Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 4/20 | 0.44 |
| ▸ | HTR6 | P50406 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 3/20 | 0.43 |
| ▸ | AURKA | O14965 | 8/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 6/20 | 0.43 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3947000 | 0.91 | ITGA1 (0.46) | PTGS2BRD4AURKAAURKBSERPINE1 | |
| SCHEMBL3945365 | 0.90 | BRD4 (0.55) | BRD4AURKAAURKBMEN1KMT2A | |
| SCHEMBL3948051 | 0.88 | GPR27 (0.46) | HTR6BRD4AURKAAURKBSERPINE1 | |
| SCHEMBL3942914 | 0.87 | HTR6 (0.41) | PTGS2HTR6BRD4AURKAAURKB | |
| SCHEMBL3948032 | 0.87 | SERPINE1 (0.55) | HTR6BRD4AURKAAURKBSERPINE1 | |
| SCHEMBL3947998 | 0.86 | BRD4 (0.52) | BRD4MEN1KMT2ASERPINE1 | |
| SCHEMBL3951295 | 0.86 | BRD4 (0.52) | HTR6BRD4AURKAAURKBMEN1 | |
| SCHEMBL3942384 | 0.85 | BRD4 (0.52) | BRD4AURKAAURKBMEN1KMT2A | |
| SCHEMBL3943378 | 0.85 | BRD4 (0.52) | BRD4MEN1KMT2ASERPINE1 | |
| SCHEMBL3944674 | 0.85 | BRD4 (0.52) | BRD4MEN1KMT2ASERPINE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1802572-B1 | INDOL DERIVATIVES AS INHIBITORS OF SOLUBLE ADENYLYL CYCLASE | BAYER SCHERING PHARMA AG (DE) | 2009-04-22 | — | — | EP | disclosed |
| EP-1802572-A1 | INDOL DERIVATIVES AS INHIBITORS OF SOLUBLE ADENYLYL CYCLASE | Bayer Schering Pharma Aktiengesellschaft (DE) | 2007-07-04 | — | — | EP | disclosed |
| WO-2006032541-A1 | INDOL DERIVATIVES AS INHIBITORS OF SOLUBLE ADENYLYL CYCLASE | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2006-03-30 | — | — | WO | disclosed |