Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | DRD4 | P21917 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3538922 | 1.00 | HTR4 (0.47) | HTR4KDM4EMEN1MAPTKMT2A | |
| SCHEMBL1163804 | 0.93 | KDM4E (0.51) | HTR4KDM4EMEN1MAPTKMT2A | |
| SCHEMBL3543445 | 0.88 | PIK3CA (0.46) | HTR4KDM4EMEN1MAPTKMT2A | |
| SCHEMBL3943811 | 0.88 | PIK3CA (0.46) | HTR4KDM4EMEN1MAPTKMT2A | |
| SCHEMBL3540628 | 0.87 | USP30 (0.47) | — | |
| SCHEMBL3936908 | 0.87 | USP30 (0.47) | — | |
| SCHEMBL13354956 | 0.86 | PTK2 (0.49) | MEN1KMT2A | |
| SCHEMBL3936693 | 0.84 | HTR4 (0.51) | HTR4DRD4 | |
| SCHEMBL3552993 | 0.84 | HTR4 (0.51) | HTR4DRD4 | |
| SCHEMBL13880913 | 0.84 | HTR4 (0.68) | HTR4KDM4EMEN1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2046793-A2 | FUSED PYRIMIDO COMPOUNDS | AstraZeneca AB (SE) | 2009-04-15 | — | — | EP | disclosed |
| WO-2008040951-A1 | COMPOUNDS | ASTRAZENECA AB (SE) | 2008-04-10 | — | — | WO | disclosed |
| WO-2008003958-A2 | FUSED PYRIMIDO COMPOUNDS | ASTRAZENECA AB (SE) | 2008-01-10 | — | — | WO | disclosed |