Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 13/20 | 0.70 |
| ▸ | CSF1R | P07333 | 6/20 | 0.64 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1867382 | 0.90 | NPC1 (0.63) | CSF1RNPC1CYP11B2 | |
| SCHEMBL3941877 | 0.87 | BRAF (0.83) | BRAFCSF1RNPC1CYP11B2 | |
| SCHEMBL3941714 | 0.84 | BRAF (0.83) | BRAFCSF1R | |
| SCHEMBL1276903 | 0.83 | BRAF (1.00) | BRAFCSF1RCYP11B2 | |
| SCHEMBL4020821 | 0.83 | CSF1R (0.83) | BRAFCSF1RNPC1 | |
| SCHEMBL3934829 | 0.82 | BRAF (0.83) | BRAFCSF1RCYP11B2 | |
| SCHEMBL1276331 | 0.82 | BRAF (0.76) | BRAFCSF1RCYP11B2 | |
| SCHEMBL3937724 | 0.82 | CSF1R (0.83) | BRAFCSF1RNPC1CYP11B2 | |
| SCHEMBL3935960 | 0.81 | BRAF (0.68) | BRAFCSF1RNPC1CYP11B2 | |
| SCHEMBL27720411 | 0.81 | CYP11B2 (0.76) | BRAFCSF1RNPC1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831198-B1 | PYRIDINE CARBOXAMIDE DERIVATIVES FOR USE AS ANTICANCER AGENTS | ASTRAZENECA AB (SE) | 2009-04-08 | — | — | EP | disclosed |
| CN-101128454-A | Pyridine carboxamide derivatives for use as anticancer agents | ASTRAZENECA AB (SE) | 2008-02-20 | — | — | CN | disclosed |