Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR4 | P31391 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | RGS12 | O14924 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | APEX1 | P27695 | 1/20 | 0.42 |
| ▸ | THPO | P40225 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.42 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3934276 | 0.88 | ALDH1A1 (0.46) | SSTR4GAATSHRNFKB1TDP1 | |
| SCHEMBL7852494 | 0.81 | SSTR4 (0.52) | SSTR4TSHRALDH1A1KDM4ELMNA | |
| SCHEMBL30174862 | 0.81 | SSTR4 (0.46) | SSTR4LMNAMAPTHPGDBLM | |
| SCHEMBL25516873 | 0.81 | SSTR4 (0.46) | SSTR4LMNAMAPTHPGDBLM | |
| SCHEMBL25516985 | 0.81 | SSTR4 (0.50) | SSTR4HDAC3HDAC1HDAC2NCOR2 | |
| SCHEMBL30174644 | 0.81 | SSTR4 (0.50) | SSTR4HDAC3HDAC1HDAC2NCOR2 | |
| SCHEMBL27767983 | 0.78 | SSTR4 (0.43) | SSTR4GAAALDH1A1KDM4EHPGD | |
| SCHEMBL4128906 | 0.76 | GLS (0.42) | SSTR4HDAC3HDAC1HDAC2NCOR2 | |
| SCHEMBL15055377 | 0.76 | SSTR4 (0.54) | SSTR4TSHRALDH1A1KDM4ELMNA | |
| SCHEMBL2112935 | 0.75 | HDAC3 (0.54) | SSTR4ALDH1A1LMNAHDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044017-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2009-04-08 | — | — | EP | disclosed |
| WO-2007146838-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2007-12-21 | — | — | WO | disclosed |