Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 9/20 | 0.80 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.65 |
| ▸ | NPC1 | O15118 | 1/20 | 0.65 |
| ▸ | RAB9A | P51151 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.65 |
| ▸ | CSF1R | P07333 | 5/20 | 0.64 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.57 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3944890 | 0.91 | CSF1R (0.78) | BRAFALDH1A1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL3937788 | 0.89 | BRAF (0.81) | BRAFALDH1A1MEN1NPC1RAB9A | |
| SCHEMBL3935730 | 0.89 | BRAF (1.00) | BRAFALDH1A1MEN1NPC1RAB9A | |
| SCHEMBL3936515 | 0.88 | CSF1R (0.83) | BRAFALDH1A1MEN1NPC1RAB9A | |
| SCHEMBL3941916 | 0.86 | MAPK1 (0.79) | BRAFALDH1A1NPC1RAB9AKMT2A | |
| SCHEMBL3935559 | 0.85 | BRAF (0.80) | BRAFCSF1RCYP11B1CYP11B2 | |
| SCHEMBL3931363 | 0.85 | CSF1R (0.80) | BRAFCSF1RCYP11B1CYP11B2 | |
| SCHEMBL3939077 | 0.84 | BRAF (0.66) | BRAFALDH1A1MEN1NPC1RAB9A | |
| SCHEMBL3936478 | 0.84 | CSF1R (0.81) | BRAFMEN1KMT2ACSF1RCYP11B1 | |
| SCHEMBL3941905 | 0.83 | CSF1R (0.77) | BRAFMEN1KMT2ACSF1RCYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831198-B1 | PYRIDINE CARBOXAMIDE DERIVATIVES FOR USE AS ANTICANCER AGENTS | ASTRAZENECA AB (SE) | 2009-04-08 | — | — | EP | disclosed |
| CN-101128454-A | Pyridine carboxamide derivatives for use as anticancer agents | ASTRAZENECA AB (SE) | 2008-02-20 | — | — | CN | disclosed |