Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 16/20 | 0.44 |
| ▸ | EGFR | P00533 | 14/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 10/20 | 0.44 |
| ▸ | FLT1 | P17948 | 10/20 | 0.44 |
| ▸ | FLT4 | P35916 | 10/20 | 0.44 |
| ▸ | EPHA2 | P29317 | 3/20 | 0.38 |
| ▸ | RET | P07949 | 3/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.36 |
| ▸ | TEK | Q02763 | 2/20 | 0.36 |
| ▸ | KIF5B | P33176 | 2/20 | 0.36 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.36 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.36 |
| ▸ | PLK4 | O00444 | 1/20 | 0.36 |
| ▸ | CIT | O14578 | 1/20 | 0.36 |
| ▸ | GAK | O14976 | 1/20 | 0.36 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.36 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | STK10 | O94804 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4780880 | 0.77 | EGFR (0.49) | KDREGFRFGFR1FLT1FLT4 | |
| SCHEMBL1008026 | 0.74 | KDR (0.72) | KDREGFRFGFR1FLT1FLT4 | |
| Water SCHEMBL27735443 | 0.73 | KDR (0.71) | KDREGFRFGFR1FLT1FLT4 | |
| Hydrochloric Acid SCHEMBL6454560 | 0.73 | KDR (0.71) | KDREGFRFGFR1FLT1FLT4 | |
| SCHEMBL5506368 | 0.69 | EGFR (0.56) | KDREGFRFGFR1FLT1FLT4 | |
| Trifluoroacetic Acid SCHEMBL6902285 | 0.69 | KDR (0.65) | KDREGFRFGFR1FLT1FLT4 | |
| SCHEMBL5506712 | 0.68 | KDR (0.45) | KDREGFRFGFR1FLT1FLT4 | |
| SCHEMBL5505229 | 0.68 | EGFR (0.60) | KDREGFR | |
| SCHEMBL2200083 | 0.67 | EGFR (0.73) | KDREGFRFGFR1FLT1FLT4 | |
| SCHEMBL3692729 | 0.67 | FGFR1 (0.49) | KDREGFRFGFR1FLT1FLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009019518-A1 | PYRIMIDINE COMPOUNDS HAVING A FGFR INHIBITORY EFFECT | ASTRAZENECA AB (SE) | 2009-02-12 | — | — | WO | disclosed |