Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 11/20 | 0.49 |
| ▸ | KDR | P35968 | 10/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 9/20 | 0.49 |
| ▸ | FLT1 | P17948 | 9/20 | 0.49 |
| ▸ | FLT4 | P35916 | 9/20 | 0.49 |
| ▸ | RET | P07949 | 2/20 | 0.44 |
| ▸ | KIF5B | P33176 | 2/20 | 0.44 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.42 |
| ▸ | ALK | Q9UM73 | 7/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.40 |
| ▸ | TEK | Q02763 | 2/20 | 0.40 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.40 |
| ▸ | PLK4 | O00444 | 1/20 | 0.40 |
| ▸ | CIT | O14578 | 1/20 | 0.40 |
| ▸ | GAK | O14976 | 1/20 | 0.40 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.40 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | STK10 | O94804 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3692729 | 0.90 | FGFR1 (0.49) | EGFRKDRFGFR1FLT1FLT4 | |
| SCHEMBL7797258 | 0.84 | KDR (0.59) | EGFRKDRFGFR1FLT1FLT4 | |
| SCHEMBL1008026 | 0.82 | KDR (0.72) | EGFRKDRFGFR1FLT1FLT4 | |
| Water SCHEMBL27735443 | 0.81 | KDR (0.71) | EGFRKDRFGFR1FLT1FLT4 | |
| Hydrochloric Acid SCHEMBL6454560 | 0.81 | KDR (0.71) | EGFRKDRFGFR1FLT1FLT4 | |
| SCHEMBL3944307 | 0.77 | KDR (0.44) | EGFRKDRFGFR1FLT1FLT4 | |
| SCHEMBL6478589 | 0.76 | KDR (0.49) | EGFRKDRFGFR1FLT1FLT4 | |
| Trifluoroacetic Acid SCHEMBL6902285 | 0.76 | KDR (0.65) | EGFRKDRFGFR1FLT1FLT4 | |
| SCHEMBL3668398 | 0.76 | EGFR (0.69) | EGFRKDRFGFR1FLT1FLT4 | |
| SCHEMBL2200924 | 0.73 | KDR (0.74) | EGFRKDRFGFR1FLT1FLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013148638-A2 | COMPOSITIONS AND METHODS RELATED TO INHIBITORS OF JAK KINASE | EP PHARMA, INC. (US) | 2013-10-03 | — | — | WO | disclosed |
| EP-1922307-A2 | HETEROCYCLIC INHIBITORS OF MEK AND METHODS OF USE THEREOF | Array Biopharma, Inc. (US) | 2008-05-21 | — | — | EP | disclosed |
| WO-2008009909-A1 | PTERIDIMONES AS MODULATORS OF POLO-LIKE KINASE | ASTRAZENECA AB (SE) | 2008-01-24 | — | — | WO | disclosed |
| WO-2007044084-A2 | HETEROCYCLIC INHIBITORS OF MEK AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC. (US) | 2007-04-19 | — | — | WO | disclosed |