Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NSD1 | Q96L73 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | NSD2 | O96028 | 1/20 | 0.41 |
| ▸ | NSD3 | Q9BZ95 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11698907 | 0.81 | HSD17B10 (0.64) | NSD1HTTHSD17B10GAAMAPT | |
| SCHEMBL2652019 | 0.80 | CYP2C19 (0.44) | NSD1HSD17B10GAAMAPTSMN1; SMN2 | |
| SCHEMBL5530542 | 0.77 | HSD17B10 (0.68) | NSD1HTTHSD17B10GAAL3MBTL1 | |
| SCHEMBL10612158 | 0.77 | NPC1 (0.43) | NSD1HSD17B10GAAMAPTSMN1; SMN2 | |
| Methane SCHEMBL10611769 | 0.77 | NPC1 (0.43) | NSD1HSD17B10GAAMAPTSMN1; SMN2 | |
| SCHEMBL8548188 | 0.76 | RAB9A (0.51) | NSD1HTTHSD17B10GAAL3MBTL1 | |
| SCHEMBL20319227 | 0.73 | CYP3A4 (0.57) | NSD1HTTHSD17B10GAAL3MBTL1 | |
| SCHEMBL8548182 | 0.73 | DRD2 (0.41) | NSD1HTTHSD17B10GAAL3MBTL1 | |
| SCHEMBL201830 | 0.72 | ALDH1A1 (0.61) | HSD17B10MAPTSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL19783109 | 0.72 | NSD1 (0.42) | NSD1HTTHSD17B10GAAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010528-A2 | 6-O-SUBSTITUTED BENZOXAZOLE AND BENZOTHIAZOLE COMPOUNDS AND METHODS OF INHIBITING CSF-1R SIGNALING | Novartis Pharma AG (CH) | 2009-01-07 | — | — | EP | disclosed |
| WO-2007121484-A2 | 6-O-SUBSTITUTED BENZOXAZOLE AND BENZOTHIAZOLE COMPOUNDS AND METHODS OF INHIBITING CSF-1R SIGNALING | NOVARTIS AG (CH) | 2007-10-25 | — | — | WO | disclosed |