Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | LGALS9 | O00182 | 1/20 | 0.37 |
| ▸ | LGALS1 | P09382 | 1/20 | 0.37 |
| ▸ | LGALS3 | P17931 | 1/20 | 0.37 |
| ▸ | LGALS7; LGALS7B | P47929 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | ABCB1 | P08183 | 8/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3944507 | 1.00 | MAPT (0.44) | MAPTLGALS9LGALS1LGALS3LGALS7; LGALS7B | |
| SCHEMBL14397682 | 1.00 | MAPT (0.44) | MAPTLGALS9LGALS1LGALS3LGALS7; LGALS7B | |
| SCHEMBL10425581 | 0.90 | MAPT (0.55) | MAPTLGALS9LGALS1LGALS3LGALS7; LGALS7B | |
| SCHEMBL26600928 | 0.84 | MAPT (0.40) | MAPTLGALS9LGALS1LGALS3LGALS7; LGALS7B | |
| SCHEMBL9815624 | 0.77 | LGALS3 (0.44) | MAPTLGALS9LGALS1LGALS3LGALS7; LGALS7B | |
| SCHEMBL9815564 | 0.76 | MAPT (0.41) | MAPTLGALS9LGALS1LGALS3LGALS7; LGALS7B | |
| SCHEMBL14110281 | 0.76 | MAPT (0.48) | MAPTLGALS9LGALS1LGALS3LGALS7; LGALS7B | |
| SCHEMBL14110284 | 0.76 | MAPT (0.48) | MAPTLGALS9LGALS1LGALS3LGALS7; LGALS7B | |
| SCHEMBL14679917 | 0.75 | MAPT (0.50) | MAPTALDH1A1KMT2APOLBMEN1 | |
| SCHEMBL14680922 | 0.75 | MAPT (0.50) | MAPTALDH1A1KMT2APOLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090118220-A1 | SUBSTITUTED ADENINES AND THE USES THEREOF | ASTRAZENECA AB (SE) | 2009-05-07 | — | — | US | disclosed |
| EP-2010553-A1 | SUBSTITUTED ADENINES AND THE USES THEREOF | AstraZeneca AB (SE) | 2009-01-07 | — | — | EP | disclosed |
| WO-2007113538-A1 | SUBSTITUTED ADENINES AND THE USES THEREOF | ASTRAZENECA AB (SE) | 2007-10-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090118220-A1 | SUBSTITUTED ADENINES AND THE USES THEREOF | HPRT1, APRT, NUDT1 | MAPT 4402/4885LGALS9 1280/4885LGALS1 1197/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.