Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 3/20 | 0.43 |
| ▸ | IL4I1 | Q96RQ9 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 6/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HTR3A | P46098 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3952865 | 0.93 | OPRM1 (0.41) | OPRM1TAAR1CYP1A2CYP2A6KDM4E | |
| SCHEMBL3954776 | 0.91 | ALDH1A1 (0.40) | OPRM1TAAR1CYP1A2CYP2A6KDM4E | |
| SCHEMBL27728990 | 0.85 | LOXL2 (0.47) | OPRM1IL4I1 | |
| SCHEMBL27668282 | 0.81 | OPRM1 (0.43) | OPRM1IL4I1KMT2ATDP1FFAR4 | |
| SCHEMBL995890 | 0.78 | OPRM1 (0.46) | OPRM1ALDH1A1L3MBTL1KMT2A | |
| SCHEMBL18983747 | 0.77 | OPRM1 (0.44) | OPRM1IL4I1ALDH1A1KMT2A | |
| SCHEMBL12967224 | 0.77 | CYP2A6 (0.47) | OPRM1IL4I1CYP2A6 | |
| SCHEMBL118612 | 0.77 | OPRM1 (0.44) | OPRM1IL4I1 | |
| SCHEMBL27729280 | 0.76 | LOXL2 (0.42) | OPRM1IL4I1KDM4EALDH1A1KMT2A | |
| SCHEMBL27340577 | 0.74 | OPRM1 (0.40) | OPRM1IL4I1KDM4EALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2051967-A1 | BENZIMIDAZOLE DERIVATIVES USEFUL IN TREATMENT OF VALLINOID RECEPTOR TRPV1 RELATED DISORDERS | AstraZeneca AB (SE) | 2009-04-29 | — | — | EP | disclosed |
| WO-2008018827-A1 | BENZIMIDAZOLE DERIVATIVES USEFUL IN TREATMENT OF VALLINOID RECEPTOR TRPV1 RELATED DISORDERS | ASTRAZENECA AB (SE) | 2008-02-14 | — | — | WO | disclosed |