Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNK3 | O14649 | 1/20 | 0.44 |
| ▸ | CSF1R | P07333 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 2/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.41 |
| ▸ | BCR | P11274 | 2/20 | 0.41 |
| ▸ | SRC | P12931 | 2/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.41 |
| ▸ | PRKCA | P17252 | 2/20 | 0.41 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3944917 | 0.94 | BACE1 (0.41) | KCNK3CSF1RSMN1; SMN2HTTABL1 | |
| SCHEMBL3944650 | 0.89 | KCNK3 (0.41) | KCNK3CSF1RKMT2ANPC1RAB9A | |
| SCHEMBL3951861 | 0.89 | GRM4 (0.41) | KCNK3SMN1; SMN2ABL1BCRSRC | |
| SCHEMBL3946988 | 0.89 | MEN1 (0.47) | KCNK3SMN1; SMN2TSHRHTTPRKCD | |
| SCHEMBL4154763 | 0.87 | KCNK3 (0.41) | KCNK3CSF1RKMT2A | |
| SCHEMBL3952707 | 0.87 | KCNK3 (0.41) | KCNK3CSF1RTSHRKMT2ARAB9A | |
| SCHEMBL3944465 | 0.85 | KCNK3 (0.44) | KCNK3SMN1; SMN2HTTABL1PDGFRB | |
| SCHEMBL3951123 | 0.85 | BACE1 (0.41) | KMT2ANPC1RAB9AMEN1CYP1A2 | |
| SCHEMBL3951875 | 0.85 | MAPT (0.42) | KCNK3SMN1; SMN2HTTABL1PDGFRB | |
| SCHEMBL3952248 | 0.84 | BACE1 (0.40) | PDGFRBSRCPDGFRAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1718632-B1 | PYRIMIDINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | SANOFI AVENTIS (FR) | 2009-04-22 | — | — | EP | claimed |