Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 5/20 | 0.40 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.33 |
| ▸ | SRC | P12931 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.33 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.33 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.33 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.33 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
| ▸ | CCR3 | P51677 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3951123 | 0.90 | BACE1 (0.41) | BACE1AURKARPS6KB1ALOX5 | |
| SCHEMBL3944917 | 0.88 | BACE1 (0.41) | BACE1AURKARPS6KB1SRCPDGFRB | |
| SCHEMBL3951861 | 0.86 | GRM4 (0.41) | BACE1SRCKDR | |
| SCHEMBL3944465 | 0.84 | KCNK3 (0.44) | BACE1ALDH1A1EGFRPDGFRBPDGFRA | |
| SCHEMBL3945805 | 0.84 | LMNA (0.44) | AURKARPS6KB1SRCALDH1A1PDGFRB | |
| SCHEMBL3946482 | 0.84 | ALOX5 (0.39) | ALDH1A1ALOX5 | |
| SCHEMBL3944601 | 0.84 | KCNK3 (0.44) | SRCALDH1A1PDGFRBPDGFRA | |
| SCHEMBL3944650 | 0.84 | KCNK3 (0.41) | BACE1ALDH1A1 | |
| SCHEMBL3951875 | 0.84 | MAPT (0.42) | BACE1SRCALDH1A1PDGFRBPDGFRA | |
| SCHEMBL3946988 | 0.83 | MEN1 (0.47) | RPS6KB1FGFR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1718632-B1 | PYRIMIDINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | SANOFI AVENTIS (FR) | 2009-04-22 | — | — | EP | claimed |