Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNK3 | O14649 | 1/20 | 0.41 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.35 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | GHSR | Q92847 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | GNRHR | P30968 | 1/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.33 |
| ▸ | ATR | Q13535 | 1/20 | 0.33 |
| ▸ | CSF1R | P07333 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3944917 | 0.92 | BACE1 (0.41) | KCNK3KCNK9BACE1AURKARPS6KB1 | |
| SCHEMBL3951861 | 0.88 | GRM4 (0.41) | KCNK3KCNK9BACE1MAPT | |
| SCHEMBL3944650 | 0.87 | KCNK3 (0.41) | KCNK3KCNK9BACE1MAPTGRM5 | |
| SCHEMBL3951875 | 0.87 | MAPT (0.42) | KCNK3KCNK9HPGDBACE1MAPT | |
| SCHEMBL3944601 | 0.87 | KCNK3 (0.44) | KCNK3CSF1RKMT2A | |
| SCHEMBL3946988 | 0.87 | MEN1 (0.47) | KCNK3KCNK9RPS6KB1MAPTKMT2A | |
| SCHEMBL3952707 | 0.87 | KCNK3 (0.41) | KCNK3KCNK9BACE1AURKARPS6KB1 | |
| SCHEMBL3944465 | 0.85 | KCNK3 (0.44) | KCNK3KCNK9HPGDBACE1MAPT | |
| SCHEMBL3951123 | 0.84 | BACE1 (0.41) | BACE1AURKARPS6KB1ALOX5KMT2A | |
| SCHEMBL3952248 | 0.83 | BACE1 (0.40) | BACE1AURKARPS6KB1ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1718632-B1 | PYRIMIDINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | SANOFI AVENTIS (FR) | 2009-04-22 | — | — | EP | claimed |