Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNK3 | O14649 | 2/20 | 0.41 |
| ▸ | KCNK9 | Q9NPC2 | 2/20 | 0.41 |
| ▸ | GRM5 | P41594 | 2/20 | 0.40 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | KCNQ3 | O43525 | 2/20 | 0.38 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.38 |
| ▸ | KCNE1 | P15382 | 2/20 | 0.38 |
| ▸ | KCNQ1 | P51787 | 2/20 | 0.38 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3944917 | 0.94 | BACE1 (0.41) | KCNK3KCNK9MAPTNPC1RAB9A | |
| SCHEMBL3944601 | 0.89 | KCNK3 (0.44) | KCNK3NPC1RAB9AKMT2AMEN1 | |
| SCHEMBL3951861 | 0.89 | GRM4 (0.41) | KCNK3KCNK9MAPTNPC1RAB9A | |
| SCHEMBL4154763 | 0.87 | KCNK3 (0.41) | KCNK3KCNK9GRM5MAPTBACE1 | |
| SCHEMBL3952707 | 0.87 | KCNK3 (0.41) | KCNK3KCNK9RAB9ABACE1KMT2A | |
| SCHEMBL3944465 | 0.85 | KCNK3 (0.44) | KCNK3KCNK9MAPTTP53BACE1 | |
| SCHEMBL3951123 | 0.85 | BACE1 (0.41) | NPC1RAB9ABACE1KMT2AMEN1 | |
| SCHEMBL3951875 | 0.85 | MAPT (0.42) | KCNK3KCNK9MAPTNPC1RAB9A | |
| SCHEMBL3952248 | 0.84 | BACE1 (0.40) | BACE1ALDH1A1 | |
| SCHEMBL3951984 | 0.83 | SMN1; SMN2 (0.38) | KCNK3KCNK9MAPTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1718632-B1 | PYRIMIDINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | SANOFI AVENTIS (FR) | 2009-04-22 | — | — | EP | claimed |