Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.72 |
| ▸ | MEN1 | O00255 | 2/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.70 |
| ▸ | AR | P10275 | 4/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | MITF | O75030 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6673711 | 0.82 | ALDH1A1 (1.00) | TSHRMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL6670041 | 0.77 | ALDH1A1 (0.55) | TSHRMEN1KMT2AALDH1A1AR | |
| SCHEMBL3941669 | 0.75 | KDM4E (0.51) | TSHRMEN1KMT2AALDH1A1AR | |
| SCHEMBL27616300 | 0.74 | ALDH1A1 (0.52) | TSHRMEN1KMT2AALDH1A1AR | |
| SCHEMBL3945272 | 0.74 | ALDH1A1 (0.60) | TSHRMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL3937151 | 0.72 | ALDH1A1 (0.50) | TSHRMEN1KMT2AALDH1A1TDP1 | |
| SCHEMBL182807 | 0.72 | MAPK8 (0.57) | TSHRKMT2AALDH1A1ARTDP1 | |
| SCHEMBL3945483 | 0.72 | ALDH1A1 (0.58) | TSHRMEN1KMT2AALDH1A1TDP1 | |
| SCHEMBL27352497 | 0.72 | ALDH1A1 (0.56) | TSHRALDH1A1ARTDP1SMN1; SMN2 | |
| SCHEMBL19284385 | 0.71 | AR (0.51) | TSHRMEN1KMT2AALDH1A1AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7528140-B2 | Substituted pyrrolo[3,2-d]pyrimidines as glycogen synthase kinase (GSK) inhibitors | TEIJIN LIMITED (JP) | 2009-05-05 | — | — | US | disclosed |
| US-20050277773-A1 | Pyrrolopyrimidine derivatives | TEIJIN LIMITED (JP) | 2005-12-15 | — | — | US | disclosed |
| CN-1633436-A | Pyrrolopyrimidine derivatives | TEIJIN LTD (JP) | 2005-06-29 | — | — | CN | disclosed |
| EP-1477489-A1 | PYRROLOPYRIMIDINE DERIVATIVES | TEIJIN LIMITED (JP) | 2004-11-17 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050277773-A1 | Pyrrolopyrimidine derivatives | GSK3B, GSK3A, GSKIP | TSHR 3844/4885MEN1 1751/4885KMT2A 3128/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.