SCHEMBL182807

SCHEMBL182807

COC(=O)c1c(O)c(O)c(C(=O)OC)n1Cc1ccccc1

nearest known ligand 0.57

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
MAPK8 P45983 7/20 0.57
AR P10275 1/20 0.54
ALDH1A1 P00352 3/20 0.52
TDP1 Q9NUW8 1/20 0.52
MAPT P10636 2/20 0.52
GAA P10253 1/20 0.52
PKM P14618 1/20 0.52
THRB P10828 1/20 0.50
TSHR P16473 2/20 0.48
SMN1; SMN2 Q16637 3/20 0.47
KDM4E B2RXH2 1/20 0.47
KMT2A Q03164 1/20 0.47
CYP1A2 P05177 1/20 0.47
LMNA P02545 1/20 0.46
MAPK1 P28482 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3363334 0.95 MAPK8 (0.53) MAPK8ARALDH1A1TDP1MAPT
SCHEMBL182493 0.85 MAPT (0.62) ALDH1A1TDP1MAPTGAAPKM
SCHEMBL23760001 0.85 MAPK8 (0.56) MAPK8ALDH1A1MAPTGAAPKM
SCHEMBL34462088 0.81 MAPK8 (0.52) MAPK8ARALDH1A1TDP1MAPT
SCHEMBL182646 0.80 FOLH1 (0.49) ALDH1A1MAPTGAAPKMTSHR
SCHEMBL2723479 0.80 MAPK8 (0.51) MAPK8ARALDH1A1TDP1MAPT
SCHEMBL15458866 0.80 DRD2 (0.48) MAPK8ARALDH1A1TDP1MAPT
SCHEMBL4710289 0.78 MAPK8 (0.63) MAPK8
SCHEMBL2934311 0.77 MAPK8 (0.48) MAPK8ARALDH1A1TDP1MAPT
SCHEMBL28369978 0.76 MAPK8 (0.67) MAPK8AR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080055701-A1 SWITCHABLE WINDOW BASED ON ELECTROCHROMIC POLYMERS UNIVERSITY OF WASHINGTON (US) 2008-03-06 US claimed
CN-103044436-A Synthesis method of dimethyl 1-benzyl-3,4-ethylene dioxypyrrole-2,5-dicarboxylate CGENE TECH SUZHOU CHINA CO LTD 2013-04-17 CN disclosed
EP-1465962-B1 ELECTROCHROMIC POLYMERS AND POLYMER ELECTROCHROMIC DEVICES UNIV FLORIDA (US) 2012-01-04 EP disclosed
EP-1465962-B1 ELECTROCHROMIC POLYMERS AND POLYMER ELECTROCHROMIC DEVICES UNIV FLORIDA (US) 2012-01-04 EP disclosed
US-20100124702-A1 High Energy Composite Cathodes for Lithium Ion Batteries PHYSICAL SCIENCES, INC. (US) 2010-05-20 US disclosed
US-20100124702-A1 High Energy Composite Cathodes for Lithium Ion Batteries PHYSICAL SCIENCES, INC. (US) 2010-05-20 US disclosed
EP-1461341-B1 PROCESS FOR PREPARING A HETEROAROMATIC COMPOUND SUBSTITUTED WITH ONE OR MORE ETHER GROUPS AGFA GEVAERT (BE) 2010-01-27 EP disclosed
US-7547658-B2 Switchable window based on electrochromic polymers UNIVERSITY OF WASHINGTON (US) 2009-06-16 US disclosed
US-7505191-B2 Electrochromic monomers and polymers for a switchable window UNIVERSITY OF WASHINGTON (US) 2009-03-17 US disclosed
US-20080055701-A1 SWITCHABLE WINDOW BASED ON ELECTROCHROMIC POLYMERS UNIVERSITY OF WASHINGTON (US) 2008-03-06 US disclosed
US-7256923-B2 Switchable window based on electrochromic polymers UNIVERSITY OF WASHINGTON (US) 2007-08-14 US disclosed
EP-1756658-A2 SWITCHABLE WINDOW BASED ON ELECTROCHROMIC POLYMERS University of Washington (US) 2007-02-28 EP disclosed
US-20050200935-A1 Switchable window based on electrochromic polymers UNIVERSITY OF WASHINGTON (US) 2005-09-15 US disclosed
WO-2005084350-A2 SWITCHABLE WINDOW BASED ON ELECTROCHROMIC POLYMERS UNIVERSITY OF WASHINGTON (US) 2005-09-15 WO disclosed
EP-1465962-A1 ELECTROCHROMIC POLYMERS AND POLYMER ELECTROCHROMIC DEVICES UNIVERSITY OF FLORIDA (US) 2004-10-13 EP disclosed
US-6791738-B2 CONTROLLING COLOR, BRIGHTNESS AND ENVIRONMENTAL STABILITY; POLY- 3,4-ALKYLENEDIOXYHETEROCYCLES UNIVERSITY OF FLORIDA 2004-09-14 US disclosed
US-6734312-B2 CONDENSING HYDROXY- GROUP OF A COMPOUND HAVING HETEROAROMATIC NUCLEUS, WITH AN ALCOHOL CONTAINING ONE OR MORE PRIMARY OR SECONDARY ALCOHOL GROUPS, OPTIONALLY USING THE REDOX COUPLE OF A TRIARYL- OR TRIALKYLPHOSPHINE AND AN AZODIOXO-COMPOUND AGFA-GEVAERT (BE) 2004-05-11 US disclosed
US-20030174377-A1 Electrochromic polymers and polymer electrochromic devices UNIVERSITY OF FLORIDA 2003-09-18 US disclosed
US-20030162958-A1 Process for preparing a compound containing a heteroaromatic group with one or more ether substituents AGFA-GEVAERT (BE) 2003-08-28 US disclosed
WO-2003046106-A1 ELECTROCHROMIC POLYMERS AND POLYMER ELECTROCHROMIC DEVICES UNIVERSITY OF FLORIDA (US) 2003-06-05 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030162958-A1 Process for preparing a compound containing a heteroaromatic group with one or more ether substituents ADH1C, ADH1A, CYP2E1 MAPK8 2292/4885AR 368/4885ALDH1A1 500/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.