Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.41 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | GABRP | O00591 | 1/20 | 0.39 |
| ▸ | GABRD | O14764 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27616300 | 0.87 | ALDH1A1 (0.52) | ALDH1A1TSHRMEN1KMT2AHPGD | |
| SCHEMBL3937151 | 0.85 | ALDH1A1 (0.50) | ALDH1A1TSHRMEN1KMT2AHPGD | |
| SCHEMBL3945483 | 0.84 | ALDH1A1 (0.58) | ALDH1A1TSHRMEN1KMT2AHPGD | |
| SCHEMBL3945351 | 0.80 | ALDH1A1 (0.45) | ALDH1A1TSHRMEN1KMT2AHPGD | |
| SCHEMBL3936552 | 0.80 | ALDH1A1 (0.45) | ALDH1A1TSHRMEN1KMT2AHPGD | |
| SCHEMBL3938356 | 0.79 | ALDH1A1 (0.44) | ALDH1A1TSHRMEN1KMT2AHPGD | |
| SCHEMBL6672131 | 0.77 | ALDH1A1 (0.46) | ALDH1A1TSHRMEN1KMT2AHPGD | |
| SCHEMBL3944634 | 0.77 | TSHR (0.72) | ALDH1A1TSHRMEN1KMT2AGAA | |
| SCHEMBL7125525 | 0.74 | ALDH1A1 (0.59) | ALDH1A1TSHRMEN1KMT2AHPGD | |
| SCHEMBL6670606 | 0.73 | ALDH1A1 (0.44) | ALDH1A1TSHRMEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1383771-A1 | 9-DEAZAGUANINE DERIVATIVES AS INHIBITORS OF GSK-3 | Vertex Pharmaceuticals Incorporated (US) | 2004-01-28 | — | — | EP | disclosed |
| US-20030096813-A1 | Compositions useful as inhibitors of GSK-3 | CAO JINGRONG (US) | 2003-05-22 | — | — | US | disclosed |
| WO-2002085909-A1 | 9-DEAZAGUANINE DERIVATIVES AS INHIBITORS OF GSK-3 | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2002-10-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030096813-A1 | Compositions useful as inhibitors of GSK-3 | GSK3B, GSK3A, GSKIP | ALDH1A1 3164/4885TSHR 3679/4885MEN1 3805/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.